ChemicalBook > CAS DataBase List > BTdCPU

BTdCPU

Product Name
BTdCPU
CAS No.
1257423-87-2
Chemical Name
BTdCPU
Synonyms
BTdCPU;BTdCPU, 10 mM in DMSO;eIF2–GTP–tRNAiMetTernaryCompInhib, BTdCPU;Inhibitor,BTdCPU,Phosphatase,inhibit,Apoptosis;Urea, N-1,2,3-benzothiadiazol-6-yl-N'-(3,4-dichlorophenyl)-;1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
CBNumber
CB05476529
Molecular Formula
C13H8Cl2N4OS
Formula Weight
339.2
MOL File
1257423-87-2.mol
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BTdCPU Property

Density 
1.664±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥ 250 mg/mL (737.03 mM)
pka
11.75±0.43(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0065564
Product name
BTdCPU
Purity
99.48%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0065564
Product name
BTdCPU
Purity
99.48%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0065564
Product name
BTdCPU
Purity
99.48%
Packaging
25mg
Price
$990
Updated
2021/12/16
ChemScene
Product number
CS-0065564
Product name
BTdCPU
Purity
99.48%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0065564
Product name
BTdCPU
Purity
99.48%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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BTdCPU Chemical Properties,Usage,Production

Uses

BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone.html" class="link-product" target="_blank">Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2].

in vivo

BTdCPU (175 mg/kg; i.p.; single daily for 21 days) inhibits tumor growth without toxicity in mice xenograft breast tumors model[2].

Animal Model:Female nude mice (mice xenograft breast tumors model)[2].
Dosage:175 mg/kg
Administration:Intraperitoneal injection; single daily for 21 days
Result:Led to complete tumor stasis,which persisted for the remainder of the 3-week study
Showed good safety in mice.

References

[1] Burwick N, et al. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 Apr;55:23-32. DOI:10.1016/j.leukres.2017.01.007
[2] Chen T, et al. Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol. 2011 Jul 17;7(9):610-6. DOI:10.1038/nchembio.613

BTdCPU Preparation Products And Raw materials

Raw materials

Preparation Products

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BTdCPU Suppliers

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View Lastest Price from BTdCPU manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
BTdCPU 1257423-87-2
Price
US $110.00-1050.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-28

1257423-87-2, BTdCPURelated Search:


  • BTdCPU
  • eIF2–GTP–tRNAiMetTernaryCompInhib, BTdCPU
  • Urea, N-1,2,3-benzothiadiazol-6-yl-N'-(3,4-dichlorophenyl)-
  • 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
  • Inhibitor,BTdCPU,Phosphatase,inhibit,Apoptosis
  • BTdCPU, 10 mM in DMSO
  • 1257423-87-2
  • API