ChemicalBook > CAS DataBase List > EGFR-IN-7 (compound 34)

EGFR-IN-7 (compound 34)

Product Name: EGFR-IN-7 (compound 34)
CAS No.: 2267329-76-8
Chemical Name: EGFR-IN-7 (compound 34)
Synonyms: TQB3804;TBQ3804;EGFR-IN-7;EGFR Inhibitor 2;Egfr-IN-7(TQB3804 );TQB-3804 (EGFR-IN-7);EGFR-IN-7 (COMPOUND 34);TQB3804 (EGFR-IN-7) ，S6698;TQB 3804 EGFR-IN-7 (compound 34);HER1,EGFR IN 7,ErbB-1,EGFR,Inhibitor,inhibit,Epidermal growth factor receptor,EGFRIN7
CBNumber: CB05540385
Molecular Formula: C32H41BrN9O2P
Formula Weight: 694.6
MOL File: 2267329-76-8.mol

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EGFR-IN-7 (compound 34) Property

Boiling point:: 858.7±75.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 5 mg/mL (7.20 mM; ultrasonic and warming and adjust pH to 5 with 0.1 M HCL and heat to 60°C)
pka: 8.14±0.42(Predicted)
form: Solid
color: Light yellow to yellow
InChIKey: ZYSKXRAGBGLELB-UHFFFAOYSA-N
SMILES: C1(NC2=CC(C)=C(N3CCC(N4CCN(C)CC4)CC3)C=C2OC)=NC=C(Br)C(NC2=CC=C3C(=C2P(C)(C)=O)N=CC=N3)=N1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0101441
Product name: EGFR-IN-7
Purity: 99.76%
Packaging: 5mg
Price: $295
Updated: 2021/12/16

ChemScene

Product number: CS-0101441
Product name: EGFR-IN-7
Purity: 99.76%
Packaging: 10mg
Price: $495
Updated: 2021/12/16

ChemScene

Product number: CS-0101441
Product name: EGFR-IN-7
Purity: 99.76%
Packaging: 50mg
Price: $1300
Updated: 2021/12/16

DC Chemicals

Product number: 020460
Product name: Egfr-IN-7(TQB3804)
Packaging: 002
Price: $1700
Updated: 2021/12/16

DC Chemicals

Product number: 020460
Product name: Egfr-IN-7(TQB3804)
Packaging: 003
Price: $3400
Updated: 2021/12/16

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EGFR-IN-7 (compound 34) Chemical Properties,Usage,Production

Uses

EGFR-IN-7 is a potent, selective and orally active EGFR kinase inhibitor. EGFR-IN-7 has inhibitory effect for for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) with IC50 values of 7.92 nM and 0.218 nM, respectively. EGFR-IN-7 can be used for the research of various cancers[1].

in vivo

EGFR-IN-7 (compound 34; 5-45 mg/kg; p.o.; daily; for 13 days) shows potent anti-tumor activity in a subcutaneously implanted Ba/F 3 (Δ19del/T790M/C797S)-derived xenograft (CDX) BALB/c nude mouse resistance model^[1].
EGFR-IN-7 (25 and 50 mg/kg; p.o.; daily, for 3 weeks) has a significant inhibitory effect on tumor growth in the mouse subcutaneous xenograft PC-9 (Δ19del) model^[1].

Animal Model:	Ba/F 3 (Δ19del/T790M/C797S)-derived xenograft (CDX) BALB/c nude mice (female, 6-8 weeks, 18-22 g)^[1]
Dosage:	5, 15, 45 mg/kg
Administration:	Oral administration, daily, for 13 days
Result:	Significantly increased the half-life, the amount of exposure in plasma and tissues, had good pharmacokinetic effects in mice.

Animal Model:	Subcutaneous xenograft PC-9 (Δ19del) model^[1]
Dosage:	0-9 days: 50 mg/kg, 10-21 days: 25 mg/kg
Administration:	Oral administration, once a day, 3 weeks
Result:	Had a significant inhibitory effect on tumor growth, had a tumor-reducing effect and showed good antitumor efficacy.

IC 50

EGFR (WT): 7.92 nM (IC₅₀); EGFR (C797S/T790M/L858R): 0.218 nM (IC₅₀)

References

[1] Ling WY, et, al. Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase. WO2019015655A1.

EGFR-IN-7 (compound 34) Preparation Products And Raw materials

Raw materials

Preparation Products

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2267329-76-8, EGFR-IN-7 (compound 34)Related Search:

EGFR-IN-7 (COMPOUND 34)

EGFR-IN-7

TBQ3804

EGFR Inhibitor 2

2,4-Pyrimidinediamine, 5-bromo-N4-[5-(dimethylphosphinyl)-6-quinoxalinyl]-N2-[2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-

TQB3804

Egfr-IN-7(TQB3804 )

TQB 3804 EGFR-IN-7 (compound 34)

TQB-3804 (EGFR-IN-7)

(6-((5-Bromo-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)quinoxalin-5-yl)dimethylphosphine oxide

HER1,EGFR IN 7,ErbB-1,EGFR,Inhibitor,inhibit,Epidermal growth factor receptor,EGFRIN7

5-bromo-N4-[5-(dimethylphosphinyl)-6-quinoxalinyl]-N2-[2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine

TQB3804 (EGFR-IN-7) ，S6698

2267329-76-8

C32H41BrN9O2P