RIPK1-IN-4

Product Name: RIPK1-IN-4
CAS No.: 1481641-08-0
Chemical Name: RIPK1-IN-4
Synonyms: RIPK1-IN-4;RIPK1-IN-4, 10 mM in DMSO;RIPK1IN4,RIPK-1-IN-4,RIPK1 IN 4;Urea, N-[4-(1-amino-5-isoquinolinyl)phenyl]-N'-[5-(1,1-dimethylethyl)-3-isoxazolyl]-
CBNumber: CB05821237
Molecular Formula: C23H23N5O2
Formula Weight: 401.46
MOL File: 1481641-08-0.mol

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RIPK1-IN-4 Property

Boiling point:: 535.8±50.0 °C(Predicted)
Density: 1.305±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (622.73 mM)
pka: 12.71±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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RIPK1-IN-4 Chemical Properties,Usage,Production

Uses

RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].

IC 50

RIPK1

References

[1] Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43. DOI:10.1021/ml400382p

RIPK1-IN-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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RIPK1-IN-4 Suppliers

China 25 United States 3 Global 28

Shanghai YuanYe Biotechnology Co., Ltd.

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1481641-08-0, RIPK1-IN-4Related Search:

RIPK1-IN-4

Urea, N-[4-(1-amino-5-isoquinolinyl)phenyl]-N'-[5-(1,1-dimethylethyl)-3-isoxazolyl]-

RIPK1IN4,RIPK-1-IN-4,RIPK1 IN 4

RIPK1-IN-4, 10 mM in DMSO

1481641-08-0