WS-383
- Product Name
- WS-383
- CAS No.
- 2247544-02-9
- Chemical Name
- WS-383
- Synonyms
- WS-383;WS-383 hydrochloride;Ubiquitin conjugating enzyme,DCN1-UBC12,WS-383,E1 activating enzyme,WS 383,E3 ligating enzyme,WS383,interaction,KYSE70,E2 conjugating enzyme,cell,Ubiquitin ligase,E1/E2/E3 Enzyme,MGC-803,Inhibitor,Ubiquitin activating enzyme,inhibit
- CBNumber
- CB05821439
- Molecular Formula
- C18H21Cl2N9S2
- Formula Weight
- 498.45
- MOL File
- 2247544-02-9.mol
WS-383 Property
- storage temp.
- 4°C, away from moisture and light
- solubility
- DMSO : 7.35 mg/mL (14.75 mM; Need ultrasonic)
N-Bromosuccinimide Price
- Product number
- 7055
- Product name
- WS383
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $169
- Updated
- 2021/12/16
- Product number
- 9577EN
- Product name
- 2-[5-[[2-[(4-Chlorophenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]sulfanyl]tetrazol-1-yl]-N,N-dimethylethanamine;hydrochloride
- Packaging
- 10mg
- Price
- $232
- Updated
- 2021/12/16
- Product number
- CS-0090382
- Product name
- WS-383
- Purity
- 99.74%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- BW170250
- Product name
- WS 383 hydrochloride NEW
- Packaging
- 50mg
- Price
- $472.5
- Updated
- 2021/12/16
- Product number
- 9577EN
- Product name
- 2-[5-[[2-[(4-Chlorophenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]sulfanyl]tetrazol-1-yl]-N,N-dimethylethanamine;hydrochloride
- Packaging
- 50mg
- Price
- $687
- Updated
- 2021/12/16
WS-383 Chemical Properties,Usage,Production
Biological Activity
WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1]. WS-383 (10 μM) is against a panel of kinases such as BTK, CDKs, and EGFR [L858R] using staurosporine and BIBW 2992 as the positive controls. WS-383 showed weak inhibitory activity at 10.0 μM,it is selective to the DCN1-UBC12 interaction over the selected kinasesr[1].WS-383 (0.03-3 μM;24 hours) blocks Cul3 neddylation at 3 μM and also has certain inhibition of Cul1 neddylation at 10 μM but was not effective in inhibiting neddylation of other cullin members[1].WS-383 (0.03-3 μM;24 hours) increases Cul1, Skp1 (adaptor protein), F-box protein, and RBX1/RBX2 RING protein form SCF E3 complex. Cyclin dependent kinase inhibitor 1A (p21) and cyclin dependent kinase inhibitor 1B (p27) expression in a dose-dependent manner in MGC-803 and KYSE70 manner[1].
storage
Store at -20°C
References
[1]. Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2019 Mar 14;62(5):2772-2797.
WS-383 Preparation Products And Raw materials
Raw materials
Preparation Products
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