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3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione

Product Name
3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione
CAS No.
191732-70-4
Chemical Name
3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione
Synonyms
2-(2,6-Dioxopiperidin-3-yl)phthalimidine 5-NH2;C5 Lenalidomide;Trifarotene Impurity 5;C5 Lenalidomide, 10 mM in DMSO;C-5 Lenalidomide,C5 Lenalidomide;1,4']Bipiperidinyl-4-carboxylic acid ethyl ester;3-(5-Amino-1-oxo-2-isoindolinyl)piperidine-2,6-dione;3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione;3-(5-amino-l-oxoisoindolin- 2-yl)piperidine-2,6-dione;3-(5-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
CBNumber
CB05823413
Molecular Formula
C13H13N3O3
Formula Weight
259.26
MOL File
191732-70-4.mol
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3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione Property

Boiling point:
634.5±55.0 °C(Predicted)
Density 
1.460±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
10.83±0.40(Predicted)
form 
Solid
color 
Off-white to gray
InChI
InChI=1S/C13H13N3O3/c14-8-1-2-9-7(5-8)6-16(13(9)19)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6,14H2,(H,15,17,18)
InChIKey
WLUIQUZGNPAKRL-UHFFFAOYSA-N
SMILES
N1C(=O)CCC(N2CC3=C(C2=O)C=CC(N)=C3)C1=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
911690
Product name
C5Lenalidomide
Purity
≥95%
Packaging
100MG
Price
$310
Updated
2025/07/31
TCI Chemical
Product number
C4018
Product name
3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging
100MG
Price
$300
Updated
2025/07/31
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3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione Chemical Properties,Usage,Production

Description

3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analog that can be useful in PROTAC research.

Uses

C5 Lenalidomide (Lenalidomide 5'-amine) is a thalidomide analog and is a potent inhibitor of TNF-alpha production (IC50=100 μM in LPS stimulated human PBMC)[1].

reaction suitability

reagent type: ligand

storage

Store at -20°C

References

[1] G W Muller, et al. Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30. DOI:10.1016/s0960-894x(99)00250-4

3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione Suppliers

China 73 United States 2 Global 75
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191732-70-4, 3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dioneRelated Search:

3-amino-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-Propanamide, hydrochloride 2,6-Piperidinedione, 3-(1,3-dihydro-5-nitro-1-oxo-2H-isoindol-2-yl)- Lenalidomide Impurity 4 Lenalidomide Impurity 11 2H-Isoindole-2-butanoic acid, 4-amino-γ-(aminocarbonyl)-1,3-dihydro-1-oxo- Lenalidomide Impurity 3 Lenalidomide Impurity 13 Lenalidomide Impurity 1 Lenalidomide Impurity 1 Lenalidomide Impurity 14 Benzoic acid, 2-(dibromomethyl)-3-nitro-, methyl ester Lenalidomide Impurity 15 Lenalidomide Impurity 12 Methyl 2-(chloromethyl)-3-nitrobenzoate 2(1H)-Pyrazinone, 4-(cyclohexylcarbonyl)-3,4-dihydro-1-(2-phenylethyl)- Lenalidomide Impurity 16

  • 3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione
  • 3-(5-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
  • 2,6-Piperidinedione, 3-(5-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
  • C5 Lenalidomide
  • 2-(2,6-Dioxopiperidin-3-yl)phthalimidine 5-NH2
  • 3-(5-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
  • 3-(5-amino-l-oxoisoindolin- 2-yl)piperidine-2,6-dione
  • C-5 Lenalidomide,C5 Lenalidomide
  • 3-(5-Amino-1-oxo-2-isoindolinyl)piperidine-2,6-dione
  • Trifarotene Impurity 5
  • 1,4']Bipiperidinyl-4-carboxylic acid ethyl ester
  • C5 Lenalidomide, 10 mM in DMSO
  • 191732-70-4