-NETA

Product Name: -NETA
CAS No.: 115066-04-1
Chemical Name: -NETA
Synonyms: ?-NETA;N2)pyridinato-κ[2-(5-Methyl-1H-pyrazol-3-yl-κ3-2-propenyl)palladium Tetrafluoroborate;3-(Trimethylaminio)-1-(1-naphtyl)-1-propanone;3-(Trimethylaminio)-1-(2-naphtyl)-1-propanone;2-(α-Naphthoyl)ethyltrimethylammonium iodide;N,N,N-trimethyl-3-(naphthalen-1-yl)-3-oxopropan-1-aminium
CBNumber: CB0602624
Molecular Formula: C16H20INO
Formula Weight: 369.25
MOL File: 115066-04-1.mol

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-NETA Property

storage temp.: −20°C
solubility: DMSO: 2mg/mL, clear
form: Solid
color: White to off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0144860
Product name: α-NETA
Purity: ≥98.0%
Packaging: 5mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-0144860
Product name: α-NETA
Purity: ≥98.0%
Packaging: 10mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-0144860
Product name: α-NETA
Purity: ≥98.0%
Packaging: 25mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0144860
Product name: α-NETA
Purity: ≥98.0%
Packaging: 50mg
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-0144860
Product name: α-NETA
Purity: ≥98.0%
Packaging: 100mg
Price: $600
Updated: 2021/12/16

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-NETA Chemical Properties,Usage,Production

Uses

α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 μM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 μM) and acetylcholinesterase (AChE; IC50=300 μM). α-NETA has anti-cancer activity[1][2].

Biological Activity

Originally identified as a substrate (ChA or choline)-noncompetitive, slowly reversible choline acetyltransferase inhibitor (human ChAT/BuChE/AChE IC50 = 88 nM/33.3 μM/48.6 μM; does not affect mAChRs, AChE, ChE, CrAT, ganglionic or skeletal muscular nAChRs), α-NETA is a fluorescent molecule (Ex 255 & 297 nm; Em 427 nm) also known for its trace amine-associated receptor 5 (TAAR5 EC50 = 150 nM) agonist and chemokine-like receptor-1 antagonist (IC50 = 375 nM; 7 nM chemerin-induced CMKLR1 β-ARR2 recruitment) potencies both in cultures and in animal disease models in vivo (3-20 mg/kg via ip. or sc. in rats & mice).

in vivo

α-NETA (i.p.; 0.125 mg/kg; once every other day for 20 days) significantly decreases tumor volume and tumor weight^[3].
α-NETA (s.c. injection; 3 mg/kg or 10 mg/kg; daily; for 30 days) significantly delays the onset of EAE with 3 mg/kg, and completely suppresses clinical signs for an average of nine days with 10 mg/kg beyond the first appearance of disease in control female C57BL/6 mice^[2].

Animal Model:	BALB/c nude mice with skov3 cells^[3]
Dosage:	0.125 mg/kg
Administration:	IP; once every other day for 20 days
Result:	Significantly decreased tumor volume and tumor weight.

IC 50

ALDH1; AChE

References

[1] Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(alpha-naphthoyl)ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep;20(9):751-71. DOI:10.1016/s0031-6989(88)80715-x
[2] Graham KL, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS One. 2014 Dec 1;9(12):e112925. DOI:10.1371/journal.pone.0112925
[3] Qiao L, et al. α-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway. FASEB J. 2019 Nov;33(11):12760-12767. DOI:10.1096/fj.201900483RR

-NETA Preparation Products And Raw materials

Raw materials

Preparation Products

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-NETA Suppliers

China 27 Switzerland 1 United States 3 Global 31

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
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Suzhou Chenrui Biotechnology Co. LTD

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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
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TargetMol Chemicals Inc.

Tel: 4008200310
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Shanghai Tachizaki Biomedical Research Center

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G-CLONE

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hubei PharmaStandard Co., Ltd.

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Sichuan Boyou Biotechnology Co., Ltd

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Jiangsu Aosaikang Pharmaceutical Co., Ltd

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Merck KGaA

Tel: 21-20338288
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115066-04-1, -NETARelated Search:

ETHYLTRIMETHYLAMMONIUM IODIDE

[2-(5-Methyl-1H-pyrazol-3-yl-&kappa

3-2-propenyl)palladium Tetrafluoroborate

N2)pyridinato-&kappa

?-NETA

2-(α-Naphthoyl)ethyltrimethylammonium iodide

3-(Trimethylaminio)-1-(2-naphtyl)-1-propanone

3-(Trimethylaminio)-1-(1-naphtyl)-1-propanone

N,N,N-trimethyl-3-(naphthalen-1-yl)-3-oxopropan-1-aminium

115066-04-1

C16H20NOI