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PKUMDL-LC-101-D04

Product Name
PKUMDL-LC-101-D04
CAS No.
2143896-83-5
Chemical Name
PKUMDL-LC-101-D04
Synonyms
PKUMDL-LC-101-D04;GPX4-Activator-1d4;PKUMDL-LC-101-D04 HCl;GPX4-Activator-1d4 Hydrochloride;PKUMDL LC 101 D04,PKUMDL-LC-101-D-04,PKUMDLLC101D04;N-(2-Aminoethyl)-4-(3-cyclopentylthioureido)benzenesulfonamide hydrochloride;N-(2-aminoethyl)-4-[[(cyclopentylamino)thioxomethyl]amino]-benzenesulfonamide, monohydrochloride
CBNumber
CB06197722
Molecular Formula
C14H23ClN4O2S2
Formula Weight
378.93
MOL File
2143896-83-5.mol
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PKUMDL-LC-101-D04 Property

storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A crystalline solid
color 
White to off-white
Water Solubility 
H2O: 2mg/mL, clear
InChIKey
FELDRJSFLBINQS-UHFFFAOYSA-N
SMILES
S=C(NC1=CC=C(C=C1)S(NCCN)(=O)=O)NC2CCCC2.Cl
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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PKUMDL-LC-101-D04 Chemical Properties,Usage,Production

Description

PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.

Uses

PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation[1][2].

References

1. Li, C., Deng, X., Zhang, W., et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4 J. Med. Chem. 62(1),266-275(2019).

PKUMDL-LC-101-D04 Preparation Products And Raw materials

Raw materials

Preparation Products

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PKUMDL-LC-101-D04 Suppliers

China 29 United States 2 Global 31
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9532
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
Wuxi Donghe Pharmaceutical Technology Co., Ltd.
Tel
63313187 15358055255
Fax
QQ：63313187
Email
63313187@qq.com
Country
China
ProdList
1985
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4989
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58
Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58

2143896-83-5, PKUMDL-LC-101-D04Related Search:


  • PKUMDL-LC-101-D04
  • GPX4-Activator-1d4
  • PKUMDL LC 101 D04,PKUMDL-LC-101-D-04,PKUMDLLC101D04
  • N-(2-aminoethyl)-4-[[(cyclopentylamino)thioxomethyl]amino]-benzenesulfonamide, monohydrochloride
  • N-(2-Aminoethyl)-4-(3-cyclopentylthioureido)benzenesulfonamide hydrochloride
  • PKUMDL-LC-101-D04 HCl
  • GPX4-Activator-1d4 Hydrochloride
  • 2143896-83-5