TOPOTECAN-D6

Product Name: TOPOTECAN-D6
CAS No.: 1044904-10-0
Chemical Name: TOPOTECAN-D6
Synonyms: Hycamtin-d6;TOPOTECAN-D6;NSC-609669-d6;SKF-104864A-d6;[2H6]-Topotecan;Topotecan dihydrochloride salt;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CBNumber: CB0649948
Molecular Formula: C23H23N3O5
Formula Weight: 421.45
MOL File: 1044904-10-0.mol

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TOPOTECAN-D6 Property

Melting point:: 213-218°C (dec)
storage temp.: -20°C Freezer
solubility: aqueous acid: soluble; DMSO: slightly; Methanol: soluble
form: A solid
color: Light yellow to yellow
Stability:: Hygroscopic
CAS DataBase Reference: 1044904-10-0

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29082
Product name: Topotecan-d6
Packaging: 500μg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 29082
Product name: Topotecan-d6
Packaging: 1mg
Price: $299
Updated: 2024/03/01

Usbiological

Product number: T8067-11
Product name: Topotecan-d6
Packaging: 1mg
Price: $460
Updated: 2021/12/16

TRC

Product number: T542502
Product name: Topotecan-d6
Packaging: 10mg
Price: $1455
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0005320
Product name: TOPOTECAN-D6
Purity: 95.00%
Packaging: 100MG
Price: $1871.1
Updated: 2021/12/16

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TOPOTECAN-D6 Chemical Properties,Usage,Production

Description

Topotecan-d₆ is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC₅₀ values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC₅₀s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.

Chemical Properties

Light Yellow to Greenish Powder

Uses

Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic

Uses

Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.

TOPOTECAN-D6 Preparation Products And Raw materials

Raw materials

Preparation Products

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TOPOTECAN-D6 Suppliers

Canada 2 China 19 France 1 India 1 United States 4 Global 27

Toronto Research Chemicals

Tel: --
Fax: --
Email: info@trc-canada.com
Country: Canada
ProdList: 6038
Advantage: 71

TLC PharmaChem Inc.

Tel: --
Fax: --
Email: research@tlcpharmachem.com
Country: Canada
ProdList: 921
Advantage: 60

1044904-10-0, TOPOTECAN-D6Related Search:

Topotecan Carboxylic Acid Sodium Salt Topotecan

TOPOTECAN-D6

(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

SKF-104864A-d6

(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Hycamtin-d6

NSC-609669-d6

(4S)-10-[[Di(methyl-d<sub>3</sub>)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

[2H6]-Topotecan

Topotecan dihydrochloride salt

1044904-10-0

C23H17D6N3O5

C23H17N3O5D6

Heterocycles

Isotope Labelled Compounds

Inhibitors

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Pharmaceuticals