2-T-BUTYLTHIOPHENE

2-T-BUTYLTHIOPHENE Property

Melting point:

-59.1°C

Boiling point:

163.95°C

Density 

0.9967 (estimate)

refractive index 

1.5197 (estimate)

storage temp. 

2-8°C(protect from light)

solubility 

Chloroform, Methanol (Slightly)

form 

Oil

color 

Colourless

LogP

3.558 (est)

EPA Substance Registry System

2-tert-Butylthiophene (1689-78-7)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

2-T-BUTYLTHIOPHENE Chemical Properties,Usage,Production

Synthesis

A dichloromethane (30 mL) solution of thiophene (12.0 g, 0.143 mol) and bromo-tert-butane (19.6 g, 0.143 mol) was slowly added dropwise to a suspension of dichloromethane (30 mL) containing aluminum trichloride (19.1 g, 0.143 mol) at -78 °C for a controlled period of 1 hour. The reaction mixture was stirred continuously at -78 °C for 2 hours, followed by slow warming to room temperature and continued stirring for 18 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and washed sequentially with water, 5% sodium hydroxide solution and water. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was purified by vacuum distillation (20 mmHg) to give 10.7 g of 2-(tert-butyl)thiophene in 53% yield.

References

[1] Patent: US2004/10013, 2004, A1. Location in patent: Page/Page column 65