ChemicalBook > CAS DataBase List > 5-FLUOROGRAMINE

5-FLUOROGRAMINE

Product Name: 5-FLUOROGRAMINE
CAS No.: 343-90-8
Chemical Name: 5-FLUOROGRAMINE
Synonyms: 5-FLUOROGRAMINE;5-Fluorogramine 98%;3-(dimethylamino)methyl-5-fluoro-indol;5-FLUORO-3-(DIMETHYLAMINOMETHYL)INDOLE;5-FLUORO-3-DIMETHYLAMINOMETHYL-1H-INDOLE;3-((dimethylamino)methyl)-5-fluoroindole;3-(Dimethylaminomethyl)-5-fluoro-1H-indole;5-fluoro-n,n-dimethyl-1h-indole-3-methanamin;(5-FLUORO-1H-INDOL-3-YLMETHYL)-DIMETHYL-AMINE;5-Fluoro-N,N-dimethyl-1H-indole-3-methanamine
CBNumber: CB0667137
Molecular Formula: C11H13FN2
Formula Weight: 192.23
MOL File: 343-90-8.mol

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5-FLUOROGRAMINE Property

Melting point:: 145-149°C
storage temp.: 2-8°C(protect from light)
Appearance: White to off-white Solid
CAS DataBase Reference: 343-90-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: F621095
Product name: 5-Fluorogramine
Packaging: 500mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: W5597
Product name: 1-(5-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
Packaging: 250mg
Price: $117
Updated: 2021/12/16

AK Scientific

Product number: W5597
Product name: 1-(5-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
Packaging: 1g
Price: $136
Updated: 2021/12/16

Matrix Scientific

Product number: 119741
Product name: 1-(5-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
Purity: 95+%
Packaging: 1g
Price: $168
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0024923
Product name: 5-FLUOROGRAMINE
Purity: 95.00%
Packaging: 5MG
Price: $495.9
Updated: 2021/12/16

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5-FLUOROGRAMINE Chemical Properties,Usage,Production

Synthesis

399-52-0

50-00-0

124-40-3

343-90-8

5-Fluoroindole (1.0 g, 7.40 mmol) was dissolved in 1 mL of acetic acid, and the solution was slowly added dropwise to a mixture of dimethylamine (567 mg, 1.42 mL, 12.58 mmol, 40% aqueous solution) and formaldehyde (333 mg, 0.9 mL, 11.09 mmol, 37% aqueous solution) that had been pre-cooled to 0°C. The reaction was carried out under argon protection . The reaction mixture was stirred without cooling for 3 hours. Upon completion of the reaction, the mixture was poured into 20 mL of ice water and the pH was adjusted with base to 11. Subsequently, the organic products in the aqueous phase were extracted with ether, the organic phases were combined and dried with anhydrous magnesium sulfate. After removal of the solvent by evaporation under reduced pressure, the crude product was purified by silica gel column chromatography with chloroform/methanol/ammonia as eluent (90:10:1 to 40:10:1 gradient elution) to afford the target compound 1-(5-fluoro-1H-indol-3-yl)-N,N-dimethylmethylmethaneamine (1.33 g, 6.92 mmol, 93% yield) as a beige solid. The structure of the product was confirmed by 1H NMR and 13C NMR: 1H NMR (400 MHz, CDCl3) δ 8.47 (s, 1H), 7.36-7.31 (m, 1H), 7.25-7.20 (m, 1H), 7.12 (d, J = 2.6 Hz, 1H), 6.95-6.88 (m, 1H), 3.58 (s, 2H), 2.28 (s, 6H), 3.58 (s, 2H), 3.58 (s, 2H), 3.58 (s, 2H) 2.28 (s, 6H); 13C NMR (100 MHz, CDCl3) δ 157.5 (d, J = 234.4 Hz), 132.4, 128.0 (d, J = 9.9 Hz), 125.1, 113.2 (d, J = 4.9 Hz), 111.3 (d, J = 9.7 Hz), 110.0 (d, J = 26.4 Hz ), 103.87 (d, J = 23.5 Hz), 54.1, 44.9.

References

[1] Journal of Biological Chemistry, 2016, vol. 291, # 38, p. 20068 - 20084
[2] Journal of Organic Chemistry, 2018, vol. 83, # 17, p. 9902 - 9913
[3] Journal of the Chemical Society, 1959, p. 1913
[4] Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1954, vol. 297, p. 229,233

5-FLUOROGRAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-FLUOROGRAMINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-FLUOROGRAMINE 343-90-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

343-90-8, 5-FLUOROGRAMINERelated Search:

6-FLUOROGRAMINE 4-FLUOROGRAMINE 7-Fluorogramine Flutroline Carvotroline 4'-FLUORO-4-(8-FLUORO-1,3,4,5-TETRAHYDRO-2H-PYRIDOó4,3-B]INDOL-2-YL)BUTYROPHENONEHCL,99% Gevotroline 2-ACETYL-8-FLUORO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE AKOS JY2083417 ETHYL 8-FLUORO-1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE-2-CARBOXYLATE 5-FLUOROGRAMINE

3-((dimethylamino)methyl)-5-fluoroindole

3-(dimethylamino)methyl-5-fluoro-indol

5-fluoro-n,n-dimethyl-1h-indole-3-methanamin

(5-FLUORO-1H-INDOL-3-YLMETHYL)-DIMETHYL-AMINE

5-FLUORO-3-DIMETHYLAMINOMETHYL-1H-INDOLE

5-FLUORO-3-(DIMETHYLAMINOMETHYL)INDOLE

5-FLUOROGRAMINE

3-(Dimethylaminomethyl)-5-fluoro-1H-indole

5-Fluoro-N,N-dimethyl-1H-indole-3-methanamine

5-Fluorogramine 98%

1H-Indole-3-methanamine, 5-fluoro-N,N-dimethyl-

343-90-8

C11H13FN2

Indoles and derivatives