DOTHIEPIN HCL
- Product Name
- DOTHIEPIN HCL
- CAS No.
- 897-15-4
- Chemical Name
- DOTHIEPIN HCL
- Synonyms
- DOSULEPIN HCL;DOTHIEPIN HYDROCHLORIDE;Dothiepin-d6 HCl;Altapin;Depresym;DOTHIEPIN HCL;dosulepinchloride;dosulepinhydrochloride;prothiadenhydrochloride;Nalidixic Acid Impurity 10
- CBNumber
- CB0667773
- Molecular Formula
- C19H22ClNS
- Formula Weight
- 331.9
- MOL File
- 897-15-4.mol
DOTHIEPIN HCL Property
- Melting point:
- 218-221℃
- storage temp.
- -20°C
- solubility
- Freely soluble in water, in alcohol and in methylene chloride.
- CAS DataBase Reference
- 897-15-4
Safety
- Hazard Codes
- F,T,Xn
- Risk Statements
- 11-23/24/25-39/23/24/25-22
- Safety Statements
- 7-16-36/37-45
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
N-Bromosuccinimide Price
- Product number
- D2962000
- Product name
- Dosulepin hydrochloride
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- d2962000
- Price
- $152
- Updated
- 2024/03/01
- Product number
- D536508
- Product name
- DothiepinHydrochloride
- Packaging
- 5mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- BD164382
- Product name
- Dothiepin hydrochloride
- Packaging
- 10mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FD65010
- Product name
- Dothiepin HCl
- Packaging
- 50g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 3732BB
- Product name
- Dothiepinhydrochloride
- Packaging
- 10mg
- Price
- $124
- Updated
- 2021/12/16
DOTHIEPIN HCL Chemical Properties,Usage,Production
Chemical Properties
White or faintly yellow, crystalline powder.
Uses
Dothiepin Hydrochloride is a tricyclic antidepressant.
Uses
Monoamine reuptake inhibitor; tricyclic antidepressant
Clinical Use
Tricyclic antidepressant
Drug interactions
Potentially hazardous interactions with other drugs
Alcohol: increased sedative effect.
Analgesics: increased risk of CNS toxicity with
tramadol; possibly increased risk of side effects with
nefopam; possibly increased sedative effects with
opioids.
Anti-arrhythmics: increased risk of ventricular
arrhythmias with amiodarone - avoid; increased
risk of ventricular arrhythmias with disopyramide,
dronedarone, flecainide or propafenone - avoid with
dronedarone.
Antibacterials: increased risk of ventricular
arrhythmias with moxifloxacin and possibly
delamanid and telithromycin - avoid with
moxifloxacin.
Anticoagulants: may alter anticoagulant effect of
coumarins.
Antidepressants: enhanced CNS excitation and
hypertension with MAOIs and moclobemide -
avoid; concentration possibly increased with SSRIs;
risk of ventricular arrhythmias with citalopram
and escitalopram - avoid; possible increased risk of
convulsions with vortioxetine.
Antiepileptics: convulsive threshold lowered;
concentration reduced by carbamazepine,
phenobarbital and possibly fosphenytoin, phenytoin
and primidone.
Antimalarials: avoid with artemether/lumefantrine
and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular
arrhythmias especially with droperidol, fluphenazine,
haloperidol, pimozide, risperidone, sulpiride and
zuclopenthixol - avoid; increased antimuscarinic
effects with clozapine and phenothiazines;
concentration increased by antipsychotics
Antivirals: increased risk of ventricular arrhythmias
with saquinavir - avoid; concentration possibly
increased with ritonavir.
Atomoxetine: increased risk of ventricular
arrhythmias and possibly convulsions.
Beta-blockers: increased risk of ventricular
arrhythmias with sotalol.
Clonidine: tricyclics antagonise hypotensive
effect; increased risk of hypertension on clonidine
withdrawal.
Dapoxetine: possible increased risk of serotonergic
effects - avoid
Dopaminergics: avoid use with entacapone; CNS
toxicity reported with selegiline and rasagiline.
Metabolism
Dosulepin hydrochloride is readily absorbed from the gastrointestinal tract, and extensively demethylated by first-pass metabolism in the liver to its primary active metabolite, desmethyldothiepin (also termed northiaden). Paths of metabolism also include S-oxidation. Dosulepin is excreted in the urine, mainly in the form of its metabolites; small amounts are also excreted in the faeces. Elimination half-lives of about 14-24 and 23-46 hours have been reported for dosulepin and its metabolites, respectively. Dose in renal impairment GFR (mL/min) 20-50 Dose as in normal renal function. 10-20 Start with small dose and titrate according to response. <10 Start with small dose and titrate according to response. Dose in patients undergoing renal replacement therapies APD/CAPD Not dialysed. Dose as in GFR<10 mL/ min. HD Not dialysed. Dose as in GFR<10 mL/ min. HDF/High flux Unknown dialysability. Dose as in GFR<10 mL/min. CAV/VVHD Unknown dialysability. Dose as in GFR=10-20 mL/min. Important drug interactions Potentially hazardous interactions with other drugs Alcohol: increased sedative effect. Analgesics: increased risk of CNS toxicity with tramadol; possibly increased risk of side effects with nefopam; possibly increased sedative effects with opioids. Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone - avoid; increased risk of ventricular arrhythmias with disopyramide, dronedarone, flecainide or propafenone - avoid with dronedarone. Antibacterials: increased risk of ventricular arrhythmias with moxifloxacin and possibly delamanid and telithromycin - avoid with moxifloxacin. Anticoagulants: may alter anticoagulant effect of coumarins. Antidepressants: enhanced CNS excitation and hypertension with MAOIs and moclobemide - avoid; concentration possibly increased with SSRIs; risk of ventricular arrhythmias with citalopram and escitalopram - avoid; possible increased risk of convulsions with vortioxetine. Antiepileptics: convulsive threshold lowered; concentration reduced by carbamazepine, phenobarbital and possibly fosphenytoin, phenytoin and primidone. Antimalarials: avoid with artemether/lumefantrine and piperaquine with
DOTHIEPIN HCL Preparation Products And Raw materials
Raw materials
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