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S-METHYL-L-THIOCITRULLINE

Product Name
S-METHYL-L-THIOCITRULLINE
CAS No.
156719-41-4
Chemical Name
S-METHYL-L-THIOCITRULLINE
Synonyms
S-MTC;S MTC,SMTC;S-Me-TC, SMTC;L-Thiocitrulline2HCl;s-methylthiocitrulline;H-THIOCIT(S-ME)-OH ACOH;S-METHYL-L-THIOCITRULLINE;S-METHYL-L-THIOCITRULLINE ACETATE;L-Ornithine, N5-[imino(methylthio)methyl]-;(2S)-2-amino-5-[[amino-(methylthio)methylene]amino]valeric acid
CBNumber
CB0670742
Molecular Formula
C7H15N3O2S
Formula Weight
205.28
MOL File
156719-41-4.mol
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S-METHYL-L-THIOCITRULLINE Property

Boiling point:
369.4±52.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at 0°C
solubility 
Soluble in DMSO
pka
2.48±0.24(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Chem-Impex
Product number
07077
Product name
S-Methyl-L-thiocitrullineacetate,99%
Purity
99%
Packaging
5MG
Price
$50.4
Updated
2021/12/16
Chem-Impex
Product number
07077
Product name
S-Methyl-L-thiocitrullineacetate,99%
Purity
99%
Packaging
25MG
Price
$128.13
Updated
2021/12/16
Chem-Impex
Product number
07077
Product name
S-Methyl-L-thiocitrullineacetate,99%
Purity
99%
Packaging
100MG
Price
$384.38
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0005667
Product name
S-METHYL-L-THIOCITRULLINE
Purity
95.00%
Packaging
5MG
Price
$504.3
Updated
2021/12/16
Chem-Impex
Product number
07077
Product name
S-Methyl-L-thiocitrullineacetate,99%
Purity
99%
Packaging
250MG
Price
$772.27
Updated
2021/12/16
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S-METHYL-L-THIOCITRULLINE Chemical Properties,Usage,Production

Uses

S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.

Definition

ChEBI: An L-arginine derivative in which the guanidino NH2 group of L-arginine is replaced by a methylsufanyl group.

in vivo

S-MTC (S-methyl-L-thiocitrulline) is a selective neuronal NOS-inhibitor. Following pretreatment with S-MTC (i.c.v.), the HBO2-induced antinociception is significantly antagonized. In Experiment #2, different groups of mice are pretreated with naltrexone hydrochloride (NTX) (3.0 mg/kg, i.p.), L-NAME (1.0 μg/mouse, i.c.v.), S-MTC (1.0 μg/mouse, i.c.v.) or N5-(1-iminoethyl)-L-ornithine (L-NIO) (3.0 mg/kg, s.c.) 15-30 min prior to HBO2 treatment. The antinociceptive effect assessed 90 min after HBO2 treatment is completely abolished by NTX and L-NAME, antagonized by two-thirds by S-MTC and largely unaffected by L-NIO (F=25.57, p<0.0001)[2]. At a dose of 0.3 mg/kg, S-MTC (SMTC) causes a rise in mean blood pressure (BP). At doses of 1.0, 3.0 and 10 mg/kg, S-MTC causes falls in heart rate, rises in BP and vasoconstriction in all three vascular beds[3].

References

[1] Law A, et al. Neuroprotective and neurorescuing effects of isoform-specific nitric oxide synthase inhibitors, nitric oxide scavenger, and antioxidant against beta-amyloid toxicity. Br J Pharmacol. 2001 Aug;133(7):1114-24. DOI:10.1038/sj.bjp.0704179
[2] Zelinski LM, et al. A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygenin mice. J Pain. 2009 Feb;10(2):167-72. DOI:10.1016/j.jpain.2008.08.003
[3] Wakefield ID, et al. Comparative regional haemodynamic effects of the nitric oxide synthase inhibitors, S-methyl-L-thiocitrulline and L-NAME, in conscious rats. Br J Pharmacol. 2003 Jul;139(6):1235-43. DOI:10.1038/sj.bjp.0705351

S-METHYL-L-THIOCITRULLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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S-METHYL-L-THIOCITRULLINE Suppliers

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156719-41-4, S-METHYL-L-THIOCITRULLINERelated Search:

L-THIOCITRULLINE S-METHYL-L-THIOCITRULLINE ACETATE SALT S-Methyl-L-thiocitrulline, DiHCl S-METHYL-L-THIOCITRULLINE DIHYDROCHLORIDE,S-METHYL-L-THIOCITRULLINE, HYDROCHLORIDE S-METHYL-L-THIOCITRULLINE

  • S-METHYL-L-THIOCITRULLINE
  • S-METHYL-L-THIOCITRULLINE ACETATE
  • H-THIOCIT(S-ME)-OH ACOH
  • s-methylthiocitrulline
  • L-Thiocitrulline2HCl
  • (2S)-2-amino-5-[[amino(methylsulfanyl)methylidene]amino]pentanoic acid
  • (2S)-2-amino-5-[[amino-(methylthio)methylene]amino]valeric acid
  • (2S)-2-azanyl-5-[[azanyl(methylsulfanyl)methylidene]amino]pentanoic acid
  • S-Me-TC, SMTC
  • (S,E)-2-aMino-5-((aMino(Methylthio)Methylene)aMino)pentanoic acid
  • S-MTC
  • L-Ornithine, N5-[imino(methylthio)methyl]-
  • S MTC,SMTC
  • 156719-41-4
  • C7H15N3O2S
  • C7H15N3O2SC2H4O2