2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE

Product Name: 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE
CAS No.: 60762-57-4
Chemical Name: 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE
Synonyms: Pirlindol;Pyrazidol;Pirlindole;Pirlindolum;Unii-V39yph45fz;PIRLINDOLE MESYLATE;Pirlindole free base;Ombitasvir Impurity 6;Pirlindolum [inn-latin];16154-78-2 (Hydrochloride)
CBNumber: CB0671512
Molecular Formula: C15H18N2
Formula Weight: 226.32
MOL File: 60762-57-4.mol

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2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE Property

storage temp.: Store at RT
solubility: DMF: 1 mg/ml; DMSO: 5 mg/ml
form: A crystalline solid
color: Off-white to light yellow

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22060
Product name: Pirlindole
Purity: ≥98%
Packaging: 5mg
Price: $71
Updated: 2024/03/01

Cayman Chemical

Product number: 22060
Product name: Pirlindole
Purity: ≥98%
Packaging: 10mg
Price: $133
Updated: 2024/03/01

Cayman Chemical

Product number: 22060
Product name: Pirlindole
Purity: ≥98%
Packaging: 25mg
Price: $313
Updated: 2024/03/01

Cayman Chemical

Product number: 22060
Product name: Pirlindole
Purity: ≥98%
Packaging: 50mg
Price: $590
Updated: 2024/03/01

Tocris

Product number: 0724
Product name: Pirlindolemesylate
Packaging: 50
Price: $628
Updated: 2021/12/16

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2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE Chemical Properties,Usage,Production

Description

Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC₅₀s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). It is selective for MAO-A over MAO-B (K_is = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC₅₀ value of 7.7 μM independent of MAO-A activity.

Uses

Antidepressive;Monoamine oxidase inhibitor

Biological Activity

A highly selective reversible inhibitor of monoamine oxidase type A.

References

[1] J. BRUHWYLER J. G J F LIéGEOIS. PIRLINDOLE: A SELECTIVE REVERSIBLE INHIBITOR OF MONOAMINE OXIDASE A. A REVIEW OF ITS PRECLINICAL PROPERTIES[J]. Pharmacological research, 1997, 36 1: Pages 23-33. DOI: 10.1006/phrs.1997.0196
[2] MóNICA MORAIS. The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.[J]. Journal of Psychopharmacology, 2014, 28 12: 1178-1183. DOI: 10.1177/0269881114553646
[3] RACHEL ULFERTS. Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C[J]. Antimicrobial Agents and Chemotherapy, 2016, 60 1: 2627-2638. DOI: 10.1128/aac.02182-15

2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE Suppliers

China 31 Germany 2 Russia 1 United Kingdom 2 United States 12 Global 48

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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BOC Sciences

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Shanghai EFE Biological Technology Co., Ltd.

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Amadis Chemical Company Limited

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Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
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View Lastest Price from 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE 60762-57-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-28

60762-57-4, 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATERelated Search:

1,10-Trimethylene-2-butyl-8-methyl-1,2,3,4-tetrahydropyrazino(1,2-a)in dole hydrochloride 1H-Pyrazino(3,2,1-jk)carbazole, 2,3,3a,4,5,6-hexahydro-8-methyl-3-prop yl-, hydrochloride 10-CYCLOHEXYL-1,2,3,3A,4,5-HEXAHYDRO-6H-PYRAZINO[1,2,3-L,M]CARBAZOLE 3-BENZYL-2,3,3A,4,5,6-HEXAHYDRO-1H-PYRAZINO[3,2,1-JK]CARBAZOLE-8-CARBALDEHYDE 2-CHLORO-1-(8-METHYL-1,2,3A,4,5,6-HEXAHYDRO-PYRAZINO[3,2,1-JK]CARBAZOL-3-YL)-ETHANONE 2,3,3A,4,5,6-HEXAHYDRO-8-CYCLOHEXYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE 3-(8-METHYL-1,2,3A,4,5,6-HEXAHYDRO-PYRAZINO-[3,2,1-JK]CARBAZOL-3-YL)PROPIONIC ACID 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE 8-METHYL-1,2,3A,4,5,6-HEXAHYDRO-3H-PYRAZINO[3,2,1-JK]CARBAZOLE-3-CARBALDEHYDE

1H-Pyrazino[3,2,1-jk]carbazole,2,3,3a,4,5,6-hexahydro-8-methyl-

PIRLINDOLE MESYLATE

2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole

8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole

16154-78-2 (Hydrochloride)

Pirlindol

Pirlindol [inn-spanish, french]

Pirlindolum

Pirlindolum [inn-latin]

Unii-V39yph45fz

Pirlindole

2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE

8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino-[3,2,1-jk]carbazole methanesulfonate

Pirlindole free base

Pyrazidol

Ombitasvir Impurity 6

60762-57-4

C15H18N2CH3SO3H

Monoamine Oxidase