GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

Product Name: GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
CAS No.: 217082-58-1
Chemical Name: GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
Synonyms: APELIN-13;QRPRLSHKGPMPF;PREPRO-65-77-APELIN;Apelin (1-13) (human);APELIN-13 (HUMAN, BOVINE);apelin-13 trifluoroacetate salt;APELIN-13 (HUMAN, BOVINE, MOUSE, RAT);Apelin-13 trifluoroacetate salt >=95%;Apelin-13, human, bovine, mouse, rat (2);GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
CBNumber: CB0671552
Molecular Formula: C69H111N23O16S
Formula Weight: 1550.83
MOL File: 217082-58-1.mol

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GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Property

Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: Soluble in PBS (pH 7.2) at approximately 10 mg/ml.
pka: 3.56±0.10(Predicted)
form: Lyophilized powder
Sequence: H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A6469
Product name: Apelin-13 trifluoroacetate salt
Purity: ≥95%
Packaging: 1mg
Price: $202.8
Updated: 2024/03/01

Alfa Aesar

Product number: J66620
Product name: Apelin-13, human, bovine
Packaging: 1mg
Price: $147
Updated: 2023/06/20

Alfa Aesar

Product number: J66620
Product name: Apelin-13, human, bovine
Packaging: 0.5mg
Price: $73.4
Updated: 2021/12/16

Cayman Chemical

Product number: 13523
Product name: Apelin-13
Purity: ≥95%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 13523
Product name: Apelin-13
Purity: ≥95%
Packaging: 5mg
Price: $249
Updated: 2024/03/01

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GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Chemical Properties,Usage,Production

Uses

Apelin-13 trifluoroacetate salt has been used to determine whether apelin promotes progression of diabetic nephropathy (DN) by inducing podocyte dysfunction. It has also been used to examine the effects of apelin on myocardial infarction (MI) injury and underlying mechanisms.

Uses

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM (the EC50 values for apelin-17 and apelin-36 are 2.5 and 20 nM, respectively). It acts primarily in the periphery and central nervous system, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity. Unlike apelin-36, apelin-13 poorly blocks the entry of human immunodeficiency virus into cells.

Uses

An endogenous ligand of Apelin Receptor (APLNR/APJ receptor) that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity.

Definition

ChEBI: Apelin-13 is a 13 amino acid oligopeptide which is the ligand for the apelin receptor (also known as the APJ receptor). It exhibits hypotensive and neuroprotective effects, and may be a potential prognostic biomarker for acute ischemic stroke and multiple sclerosis. It has a role as an antihypertensive agent, a biomarker, an autophagy inhibitor, a neuroprotective agent and a human metabolite. It is a conjugate base of an apelin-13(3+).

General Description

Apelin is a regulatory peptide and a ligand of the APJ receptor. It is a member of the G protein-coupled receptor family. Apelin and APJ are broadly dispersed in the body.

Biological Activity

apelin-13 is an endogenous ligand of the apj receptor.the apelin receptor apj, one of a group of g-proteincoupled receptors (gpcr), have recently been paired with their cognate peptide ligands using ‘‘reverse pharmacology’’, and functional evidence suggests a role for this receptor in the regulation of cardiovascular function, fluid homeostasis, and as a coreceptor for hiv infection.

Biochem/physiol Actions

Apelin plays physiological roles in the cytoprotection of many internal organs. It is used to treat insulin resistance and hypertension, but it may also can act as a negative factor. Apelin also regulates cardiovascular diseases.

in vitro

apelin-13 was identified as an endogenous ligand of the apj receptor, which could activate this g protein-coupled receptor with an ec50 value of 0.37 nm. in addition, the ec50 values for apelin-17 and apelin-36 have been found to be 2.5 and 20 nm, respectively [1].

in vivo

in a previous study, urethane anaesthetised, paralysed and ventilated male sd rats were used to investigate the action of apelin-13 directly microinjected into the nucleus tractus solitarius (nts) and the rostral ventrolateral medulla (rvlm) on arterial pressure and phrenic nerve activity. results showed that apelin-13 microinjections into the nts led to either apnea or decreased phrenic nerve discharge amplitude by up to 30%. in the rvlm, apelin-13 caused increase in phrenic nerve discharge amplitude depending on the exact site of injection [2].

IC 50

0.37 nm for gpcr

References

[1] lee, d. k.,cheng, r.,nguyen, t., et al. characterization of apelin, the ligand for the apj receptor. journal of neurochemistry 74, 34-41 (2000).
[2] seyedabadi m, goodchild ak, pilowsky pm. site-specific effects of apelin-13 in the rat medulla oblongata on arterial pressure and respiration. auton neurosci. 2002 oct 31;101(1-2):32-8.
[3] a g japp, n l cruden, g barnes, n van gemeren, j mathews, j adamson, n r johnston, m a denvir, i l megson, a d flapan, d e newby. acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure. circulation 2010 april 27, 121 (16): 1818-27.

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Preparation Products And Raw materials

Raw materials

Preparation Products

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GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Suppliers

China 88 Europe 1 France 1 Germany 2 Switzerland 1 United Kingdom 1 United States 13 USA 1 Global 108

Nanjing TGpeptide Biotechnology Co.,Ltd.

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Hangzhou Peptide Biochem Co.,Ltd

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Sigma-Aldrich

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View Lastest Price from GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE manufacturers

Career Henan Chemical Co

Product: GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE 217082-58-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-13

217082-58-1, GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHERelated Search:

4,4'-Methylenebis(2,6-di-tert-butylphenol) 2,24-Dihydroxyursolic acid BAPTA-AM AROCHLOR 1232 CD163 antibody BMPO BCA3 antibody BZL-SER(BZL)-OH biotinyltyramide Anti-RRN3 BTD antibody H-LYS-PHE-ARG-ARG-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH TRIFLUOROACETATE H-LYS-PHE-ARG-ARG-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH H-ARG-ARG-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE LYS-PHE-ARG-ARG-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE H-TYR-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH APELIN (65-77) (N15-ARG 66) [HOMO SAPIENS]/[MUS MUSCULUS]/[BOS TAURUS]

apelin-13 trifluoroacetate salt

Apelin-13, human, bovine, mouse, rat (2)

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe ((2) Due to the presence of a Gln in N-terMinal position this peptide can contain the pyroglutaMic forM)

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH

L-Phenylalanine, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-

QRPRLSHKGPMPF

PREPRO-65-77-APELIN

H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

APELIN-13

APELIN-13 (HUMAN, BOVINE)

APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)

Apelin-13 (human, bovine, mouse, rat) H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH

Apelin-13 trifluoroacetate salt >=95%

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE USP/EP/BP

Apelin 13 triTFA(217082 58 1(free base)),Apelin13 triTFA(217082581(free base))

Apelin (1-13) (human)

217082-58-1

C69H111N23O16SC2F3O2

C69H111N23O16S

Apelin receptor

Peptide

Elisa Kit-Mouse Elisa Kit