7-Fluoro-6-nitro-4-hydroxyquinazoline

Product Name: 7-Fluoro-6-nitro-4-hydroxyquinazoline
CAS No.: 162012-69-3
Chemical Name: 7-Fluoro-6-nitro-4-hydroxyquinazoline
Synonyms: 7-fluoro-6-nitroquinazolin-4-ol;7-Fluoro-6-nitro-3H-quinazolin-4-one;7-Fluoro-6-nitro-1H-quina...;7-FLUORO-6-NITRO QUINAZOLINONE;7-Fluoro-6-Nitro-4(H)-Quinazoline;7-fluoro-6-nitro-quinazolin-4-one;7-Fluoro-6-nitro quinazoline-4-ol;7-fluoro-6-nitroquizolin-4(3H)-one;7-Fluoro-6-nitro-4-hydroxyquinoline;7-Fluoro-6-nitro-1H-quinazolin-4-one
CBNumber: CB0676269
Molecular Formula: C8H4FN3O3
Formula Weight: 209.13
MOL File: 162012-69-3.mol

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7-Fluoro-6-nitro-4-hydroxyquinazoline Property

Melting point:: 282-285 °C(Solv: acetic acid (64-19-7))
Boiling point:: 407.6±55.0 °C(Predicted)
Density: 1.75±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder to crystal
pka: -2.69±0.20(Predicted)
color: Light yellow to Yellow to Orange
InChI: InChI=1S/C8H4FN3O3/c9-5-2-6-4(1-7(5)12(14)15)8(13)11-3-10-6/h1-3H,(H,10,11,13)
InChIKey: VTUAEMSZEIGQRM-UHFFFAOYSA-N
SMILES: N1C2=C(C=C([N+]([O-])=O)C(F)=C2)C(=O)NC=1
CAS DataBase Reference: 162012-69-3(CAS DataBase Reference)

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Safety

Risk Statements: 36
Safety Statements: 26
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F1091
Product name: 7-Fluoro-6-nitroquinazolin-4(1H)-one
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $63
Updated: 2025/07/31

TRC

Product number: F594900
Product name: 7-Fluoro-6-nitroquinazolin-4(3H)-one
Packaging: 1g
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H55-3-14
Product name: 7-Fluoro-6-nitro-3,4-dihydroquinazolin-4-one
Purity: 98%
Packaging: 1g
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-B0788
Product name: 7-fluoro-6-nitroquinazolin-4(3H)-one
Purity: 99.59%
Packaging: 25g
Price: $58
Updated: 2021/12/16

AK Scientific

Product number: J99030
Product name: 7-Fluoro-6-nitro-4-hydroxyquinazoline
Packaging: 5g
Price: $25
Updated: 2021/12/16

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7-Fluoro-6-nitro-4-hydroxyquinazoline Chemical Properties,Usage,Production

Uses

7-Fluoro-6-nitroquinazolin-4(3H)-one, is an intermediate in the preparation of kinase inhibitors, such as ATP Site inhibitors of the Tyrosine Kinase activity of the epidermal growth factor receptor.

Synthesis

446-32-2

162012-69-3

General procedure for the synthesis of 7-fluoro-6-nitro-4-hydroxyquinazoline from 2-amino-4-fluorobenzoic acid: 2-amino-4-fluorobenzoic acid (25 g, 152 mmol) was slowly added dropwise to a mixed solution of concentrated sulfuric acid (50 mL) and concentrated nitric acid (51 mL) at 0 °C. The reaction mixture was stirred at room temperature for 1 hour and then warmed to 110°C and continued stirring for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by slowly adding ice water (300 mL). The resulting mixture was continued to be stirred for 30 min, followed by filtration to give 7-fluoro-6-nitro-4-hydroxyquinazoline solid product (25 g, 79% yield). The structure of the product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (NMR, 300 MHz, CDCl3) and mass spectrometry (MS, ESI+): NMR data: δ 12.83 (broad single peak, 1H), 8.72 (double peak, 1H), 8.32 (single peak, 1H), 7.79 (double peak, 1H); MS data: m/z 210 [M+H]+.

References

[1] Patent: WO2012/30160, 2012, A2. Location in patent: Page/Page column 25
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 4, p. 918 - 928
[3] Patent: WO2012/182, 2012, A1
[4] Patent: WO2012/356, 2012, A1
[5] Patent: EP2612860, 2013, A1

7-Fluoro-6-nitro-4-hydroxyquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Fluoro-6-nitro-4-hydroxyquinazoline Suppliers

Americas 1 Canada 1 China 342 Europe 3 Germany 3 India 12 Japan 1 United Kingdom 2 United States 38 Global 403

Jinan XuanDe Chemical Co., Ltd.

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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

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Pure Chemistry Scientific Inc.

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Adamas Reagent, Ltd.

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View Lastest Price from 7-Fluoro-6-nitro-4-hydroxyquinazoline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 7-Fluoro-6-nitro-4-hydroxyquinazoline 162012-69-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-11

Henan Aochuang Chemical Co.,Ltd.

Product: 7-Fluoro-6-nitro-4-hydroxyquinazoline 162012-69-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Nanjing Fred Technology Co., Ltd

Product: 7-chloro-6-nitroquinazolin-4(3H)-one 162012-69-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

162012-69-3, 7-Fluoro-6-nitro-4-hydroxyquinazolineRelated Search:

Cefazolin Cefazolin sodium salt 4-Hydroxyquinazoline NITROGEN DIOXIDE Fluorine 7-Fluoro-4-quinazolone 6-AMINO-3H-QUINAZOLIN-4-ONE 4-FLUORO-3-NITROBENZALDEHYDE 6-NITROQUINAZOLIN-4(3H)-ONE 2(1H)-Quinazolinone (6CI,8CI,9CI) (4-FLUORO-3-NITROPHENYL) METHANAMINE (3-fluoro-4-nitrophenyl)methanamine Benzenemethanamine, 2-amino-4-fluoro- (9CI) 2-AMINO-4-FLUORO-5-NITROTOLUENE 3-amino-4-fluorobenzamide 4-FLUORO-3-NITROBENZAMIDE 7-Fluoro-6-nitro-4-hydroxyquinazoline

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162012-69-3

C8H4FN3O3

C8H4N3O3F

Intermediate