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SENKTIDE

Product Name
SENKTIDE
CAS No.
106128-89-6
Chemical Name
SENKTIDE
Synonyms
SENKTIDE;succinyl(asp6;Senktide?, BR;SENKTIDE (6-11);SUC-DF(ME)FGLM-NH2;SUC-DF-(NMEF)-GLM-NH2;M.W. 842.1 C40H55N7O11S;Senktide trifluoroacetate salt;Suc-Asp6, Me-Phe8] Substance P;Suc-[Asp6,MePhe8]substance P(6-11)
CBNumber
CB0679033
Molecular Formula
C40H55N7O11S
Formula Weight
841.97
MOL File
106128-89-6.mol
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SENKTIDE Property

Boiling point:
1262.6±65.0 °C(Predicted)
Density 
1.290±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO : 50 mg/mL (59.38 mM; Need ultrasonic)
form 
film
pka
4.23±0.10(Predicted)
color 
colorless
Sequence
Suc-Asp-Phe-{Me-Phe}-Gly-Leu-Met-NH2
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0764
Product name
Senktide trifluoroacetate salt
Purity
≥95% (HPLC)
Packaging
500μg
Price
$138
Updated
2025/07/31
Cayman Chemical
Product number
16721
Product name
Senktide
Purity
≥98%
Packaging
500μg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
16721
Product name
Senktide
Purity
≥98%
Packaging
1mg
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
16721
Product name
Senktide
Purity
≥98%
Packaging
5mg
Price
$593
Updated
2024/03/01
Tocris
Product number
1068
Product name
Senktide
Packaging
500U
Price
$129
Updated
2021/12/16
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SENKTIDE Chemical Properties,Usage,Production

Uses

Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM). It less potently agonizes the NK1 receptor (EC50 = 35 μM) and is without effect on the NK2 receptor. Senktide is used to study the action of the NK3 receptor in cells and in animals.

Uses

Senktide is an NK3 agonist.

Biological Activity

Senktide is a selective Neurokinin NK3 tachykinin receptor agonist. Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system th at are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract.', 'Senktide treatment in follicular phase goats enhances the liberation of luteinizing hormone (LH) and advance the time of ovulation. Senktide has the ability to suppress gonadotropin-releasing hormone (GnRH) transcription. Treatment with senktide stimulates c-Fos and improve activator protein-1 (AP-1) activity.

in vivo

I.c.v. injection of Senktide causes a dose-dependent increase in total distance traveled (F6,72=6.344, P<0.001). This increase reaches statistical significance compare to the vehicle-treated group at 0.06 nmol and higher. The Senktide-induced increase in locomotor activity brought about by 0.1 nmol of Senktide is significantly and dose-dependently decreased by the tachykinin NK3 receptor antagonists talnetant at 30 mg/kg and SB222200 at 30 mg/kg, but not by osanetant, when tested in parallel in a single experiment (F7,78=10.32, P<0.001), although a non-significant reduction is observed. However, when tested using another vehicle (Vitamin E and glycofurol), osanetant does decrease activity significantly compare to Senktide-treated gerbils (F2,30=10.10, P<0.001)[1].

storage

Store at -20°C

SENKTIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SENKTIDE Suppliers

China 91 France 1 Germany 2 Switzerland 1 United Kingdom 2 United States 16 USA 1 Global 114
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1010
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
Country
China
ProdList
9979
Advantage
55
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View Lastest Price from SENKTIDE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
SENKTIDE 106128-89-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-11
Career Henan Chemical Co
Product
SENKTIDE 106128-89-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-11

106128-89-6, SENKTIDERelated Search:

SUBSTANCE P (6-11) SENKTIDE, [PHE-3,4,5-3H]-,SENKTIDE, [PHENYLALANYL-3,4,5-3H]- 3-(4-methylphenyl)propan-1-amine SUBSTANCE P (7-11) CEGABA P-METHYLAMPHETAMINE SENKTIDE ANALOG (5-11),SENKTIDE ANALOG,NH2-SENKTIDE METHYL-(2-P-TOLYL-ETHYL)-AMINE SENKTIDE

  • succinyl(asp6
  • Substance P, fragment 6-11, succinyl[Asp6, NMePhe8]
  • M.W. 842.1 C40H55N7O11S
  • N-(3-Carboxy-1-oxopropyl)-L-Asp-L-Phe-N-methyl-L-Phe-Gly-L-Leu-L-Met-NH2
  • N-(3-Carboxy-1-oxopropyl)-L-αAsp-L-Phe-N-methyl-L-Phe-Gly-L-Leu-L-Met-NH2
  • Suc-[Asp6,MePhe8]substance P(6-11)
  • [SUCCINYL-ASP6,ME-PHE8] SUBSTANCE P
  • SUCCINYL-(ASP6,N-ME-PHE8)-SUBSTANCE P (6-11)
  • [SUCCINYL-ASP6 N-ME-PHE8]-SUBSTANCE P (6-11) (SENKTIDE)
  • [SUCCINYL-ASP6,N-ME-PHE8]-SUBSTANCE P, FRAGMENT 6-11
  • SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2
  • SUCCINYL-ASP-PHE-(N-ME)PHE-GLY-LEU-MET-NH2
  • SUCCINYL-ASP-PHE-N-METHYL-PHE-GLY-LEU-MET-NH2
  • SUC-ASP-PHE-N-ME-PHE-GLY-LEU-MET-NH2
  • SUC-[ASP6, N-ME-PHE8]-SUBSTANCE P (6-11)
  • SUBSTANCE P SUCCINYL-[ASP6, N-ME-PHE8]-FRAGMENT 6-11
  • SUC-DF(ME)FGLM-NH2
  • SUC-DF-(NMEF)-GLM-NH2
  • SENKTIDE
  • SENKTIDE (6-11)
  • SELECTIVE NEUROKININ B RECEPTOR PEPTIDE
  • Senktide?, BR
  • DFFGLM (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide) trifluoroacetate salt
  • Senktide trifluoroacetate salt
  • Suc-Asp-Phe-MePhe-Gly-Leu-Met-NH2 trifluoroacetate salt
  • 4-10-Neuromedin B (swine spinal cord), N-(3-carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine-
  • L-Methioninamide, N-(3-carboxy-1-oxopropyl)-L-alpha-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-
  • N-(3-Carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine-4-10-neuromedin B (swine spinal cord)
  • Substance p (6-11), succinyl-Asp(6)-me-Phe(8)-
  • Substance p (6-11), succinyl-aspartyl(6)-methylphenylalanine(8)-
  • Succinyl-6-Asp-8-me-Phe-substance p (6-11)
  • L-Methioninamide, N-(3-carboxy-1-oxopropyl)-L-α-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-
  • Senktide,Inhibitor,inhibit,Tachykinin receptor,NK receptor,Neurokinin Receptor
  • Suc-Asp6, Me-Phe8] Substance P
  • [Succinyl-Asp6, NMePhe8]-Substance P (6-11), Senktide - 5 mg
  • Substance P [Suc-,Asp6,Me-Phe8] (6-11)
  • 106128-89-6
  • C40H55N7O11S
  • BioChemical
  • Amino Acids and Peptides
  • Agonist
  • Biochemicals and Reagents
  • Tachykinins
  • Peptides
  • peptide
  • Tachykinin receptor