6-CHLORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- Product Name
- 6-CHLORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- CAS No.
- 22246-02-2
- Chemical Name
- 6-CHLORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- Synonyms
- 6-chloro-3,4-dihydroisoquinolin-1-ol;6-Chloro-3,4-dihydro-1(2H)-isoquinolinone;6-CHLORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;6-Chloro-3,4-dihydroisoquinolin-1(2H)-one;1(2H)-Isoquinolinone, 6-chloro-3,4-dihydro-;6-chloro-1,2,3,4-tetrahydroisoquinolin-1-one
- CBNumber
- CB0684985
- Molecular Formula
- C9H8ClNO
- Formula Weight
- 181.62
- MOL File
- 22246-02-2.mol
6-CHLORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- color
- Light brown to brown
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381810
- Product name
- 6-Chloro-3,4-dihydro-2H-isoquinolin-1-one
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C381810
- Product name
- 6-Chloro-3,4-dihydro-2H-isoquinolin-1-one
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- OR939226
- Product name
- 6-Chloro-3,4-dihydro-2H-isoquinolin-1-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- P000386996
- Product name
- 6-Chloro-3,4-dihydroisoquinolin-1(2H)-one
- Purity
- 98%
- Packaging
- 1g
- Price
- $126
- Updated
- 2021/12/16
- Product number
- 4H48-5-9Z
- Product name
- 6-Chloro-3,4-dihydro-1(2H)-isoquinolinone
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
6-CHLORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Chemical Properties,Usage,Production
Synthesis
925-90-6
57381-37-0
22246-02-2
Ethylmagnesium bromide (EtMgBr, 370 mL, 1110 mmol) was added slowly and dropwise to a stirred solution of 2-bromo-5-chlorobenzonitrile (80 g, 370 mmol) in tetrahydrofuran (THF, 1000 mL) at 0 °C. The reaction mixture was kept at 0-5 °C for 5 h, followed by dropwise addition of methanol (MeOH, 500 mL). The solution continued to be stirred for 15 minutes before sodium borohydride (NaBH4, 28 g, 740 mmol) was carefully added and the resulting mixture was stirred for 16 hours at room temperature. Upon completion of the reaction, the reaction solution was poured into water and extracted with ethyl acetate (EtOAc, 3 x 200 mL). The organic layers were combined and dried with anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate=3:1) to afford 6-chloro-3,4-dihydro-isoquinolin-1-one (30 g, yield 34.6%) as a yellow oil. Mass spectrum (MS): 235.5 [M+H]+.
References
[1] Patent: WO2014/191340, 2014, A1. Location in patent: Page/Page column 37; 38
6-CHLORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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