2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
- Product Name
- 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
- CAS No.
- 40003-41-6
- Chemical Name
- 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
- Synonyms
- IFLAB-BB F2124-0223;2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLIC A&;2-BroMo-4-Methyl-5-thiazolecarboxylic acid;2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLIC ACID;2-Bromo-4-Methyl Thiazole-4-Carboxylic Acid;5-Thiazolecarboxylic acid, 2-bromo-4-methyl-;2-Bromo-4-methylthiazole-5-carboxylic acid 96%;2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID;JR-13563, 2-Bromo-4-methylthiazole-5-carboxylic acid, 97%
- CBNumber
- CB0685184
- Molecular Formula
- C5H4BrNO2S
- Formula Weight
- 222.06
- MOL File
- 40003-41-6.mol
2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Property
- Melting point:
- 158 °C (dec.)
- Boiling point:
- 349.5±22.0 °C(Predicted)
- Density
- 1.895±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.16±0.37(Predicted)
- color
- White to Light yellow to Light orange
- CAS DataBase Reference
- 40003-41-6
N-Bromosuccinimide Price
- Product number
- 646008
- Product name
- 2-Bromo-4-methylthiazole-5-carboxylic acid
- Purity
- 96%
- Packaging
- 1g
- Price
- $79.8
- Updated
- 2023/06/20
- Product number
- 646008
- Product name
- 2-Bromo-4-methylthiazole-5-carboxylic acid
- Purity
- 96%
- Packaging
- 5g
- Price
- $308
- Updated
- 2023/06/20
- Product number
- B5336
- Product name
- 2-Bromo-4-methylthiazole-5-carboxylic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $101
- Updated
- 2025/07/31
- Product number
- B685795
- Product name
- 2-Bromo-4-methyl-5-thiazolecarboxylicAcid
- Packaging
- 5g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 8H70-9-03
- Product name
- 2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid
- Purity
- 95%
- Packaging
- 25g
- Price
- $765
- Updated
- 2021/12/16
2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
2-Bromo-4-methyl-5-thiazolecarboxylic Acid, is a heterocyclic building block used for the preparation of various chemicals. It is used in the synthesis of new azole Antifungals.
Synthesis
22900-83-0
40003-41-6
General procedure for the synthesis of 2-bromo-4-methylthiazole-5-carboxylic acid from ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate: 5N aqueous NaOH solution (15 mL) was added to a solution of ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate (1 mmol) in ethanol (20 mL), and the reaction mixture was stirred for 14 h at room temperature. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled and neutralized with concentrated hydrochloric acid. The organic layer was extracted with ethyl acetate (EtOAc) and the organic phase was dried with anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by column chromatography using silica gel (60-120 mesh) as stationary phase and gradient elution with a mixed solvent of ethyl acetate and petroleum ether, which ultimately afforded 2-bromo-4-methylthiazole-5-carboxylic acid as an off-white solid in 76% yield. The structure of the product was confirmed by 1H NMR (CDCl3, δ: 13.19, s, 1H; 2.54, s, 3H) and mass spectrometry (ESI-MS, m/z: 223 [M+H]+).
References
[1] Patent: EP2604268, 2015, B1. Location in patent: Paragraph 0150-0151
[2] Russian Journal of General Chemistry, 2016, vol. 86, # 7, p. 1722 - 1729
[3] Zh. Obshch. Khim., 2016, vol. 86, # 7, p. 1722 - 1729,8
[4] Justus Liebigs Annalen der Chemie, 1890, vol. 259, p. 298
[5] Roczniki Chemii, 1972, vol. 46, p. 1647 - 1658
2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID manufacturers
- Product
- IFLAB-BB F2124-0223 40003-41-6
- Price
- US $1.00-1.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2024-08-16
- Product
- 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID 40003-41-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16