4,4-DIFLUOROAMINOETHYLPIPERIDINE
- Product Name
- 4,4-DIFLUOROAMINOETHYLPIPERIDINE
- CAS No.
- 605659-03-8
- Chemical Name
- 4,4-DIFLUOROAMINOETHYLPIPERIDINE
- Synonyms
- 4,4-DIFLUOROAMINOETHYLPIPERIDINE;4,4-Difluoropiperidine-1-ethanamine;4,4-DIFLUORO-1-PIPERIDINEETHANAMINE;1-Piperidineethanamine,4,4-difluoro-;2-(4,4-DIFLUOROPIPERIDIN-1-YL)ETHYLAMINE;2-(4,4-Difluoropiperidin-1-yl)ethanamine;1-Piperidineethanamine,4,4-difluoro-(9CI)
- CBNumber
- CB0693608
- Molecular Formula
- C7H14F2N2
- Formula Weight
- 164.2
- MOL File
- 605659-03-8.mol
4,4-DIFLUOROAMINOETHYLPIPERIDINE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Colorless to light yellow Liquid
Safety
- RIDADR
- UN2735
- HazardClass
- 8
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0045410
- Product name
- 2-(4,4-Difluoropiperidin-1-yl)ethanamine
- Purity
- ≥97.0%
- Packaging
- 100mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- PC201267
- Product name
- 2-(4,4-Difluoropiperidin-1-yl)ethanamine
- Purity
- 95+%
- Packaging
- 25mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- CS-0045410
- Product name
- 2-(4,4-Difluoropiperidin-1-yl)ethanamine
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $114
- Updated
- 2021/12/16
- Product number
- 3H30-3-6T
- Product name
- 2-(4,4-Difluoropiperidin-1-yl)ethanamine
- Purity
- 95.0%
- Packaging
- 25mg
- Price
- $167
- Updated
- 2021/12/16
- Product number
- 019581
- Product name
- 2-(4,4-Difluoropiperidin-1-yl)ethylamine
- Packaging
- 250mg
- Price
- $181
- Updated
- 2021/12/16
4,4-DIFLUOROAMINOETHYLPIPERIDINE Chemical Properties,Usage,Production
Synthesis
824413-96-9
605659-03-8
At room temperature, 2-(4,4-difluoropiperidin-1-yl)acetonitrile (480 mg, 3.0 mmol) was dissolved in tetrahydrofuran (THF, 10 mL), followed by addition of lithium aluminum hydride (LAH, 228 mg, 6.0 mmol). The reaction mixture was stirred overnight at room temperature and then quenched by slow addition of water (10 mL) and 15% aqueous sodium hydroxide (10 mL). The resulting mixture was filtered and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (dichloromethane: methanol = 10:1) to afford 2-(4,4-difluoropiperidin-1-yl)ethylamine (400 mg, 80% yield) as a yellow oil.
References
[1] Patent: WO2014/182829, 2014, A1. Location in patent: Page/Page column 131
[2] Patent: WO2015/131080, 2015, A1. Location in patent: Paragraph 00534; 00536
[3] Patent: US2006/58308, 2006, A1. Location in patent: Page/Page column 46
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 497 - 501
[5] Patent: WO2015/150449, 2015, A2. Location in patent: Page/Page column 204
4,4-DIFLUOROAMINOETHYLPIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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