ChemicalBook > CAS DataBase List > Diethyl 2-propylImidazoledicarbonate
Diethyl 2-propylImidazoledicarbonate
Uses- Product Name
- Diethyl 2-propylImidazoledicarbonate
- CAS No.
- 144689-94-1
- Chemical Name
- Diethyl 2-propylImidazoledicarbonate
- Synonyms
- OMSTint-C;Olmesartan Impurity 17;2-propyl-, diethyl ester;Intermediate of olmesartan;carbonic acid carboxy ester;4,5-diethyl-2-propyl-1H-imidazole;Diethyl 2-propylImidazoledicarbote;2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYL;Diethyl 2-propylImidazoledicarbonate;OlMesartan IMidazole Diethyl Ester IMpurity
- CBNumber
- CB0712929
- Molecular Formula
- C12H18N2O4
- Formula Weight
- 254.28
- MOL File
- 144689-94-1.mol
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Diethyl 2-propylImidazoledicarbonate Property
- Melting point:
- 86 °C
- Boiling point:
- 400.9±25.0 °C(Predicted)
- Density
- 1.160±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- powder to crystal
- pka
- 9.25±0.10(Predicted)
- color
- White to Yellow to Orange
- CAS DataBase Reference
- 144689-94-1(CAS DataBase Reference)
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Safety
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- D3765
- Product name
- Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D3765
- Product name
- Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $164
- Updated
- 2025/07/31
TRC
- Product number
- D444795
- Product name
- Diethyl-2-propylimidazole-4,5-dicarboxylate
- Packaging
- 25g
- Price
- $60
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD21814
- Product name
- Diethyl-2-propylimidazole-4,5-dicarboxylate
- Packaging
- 5G
- Price
- $173.6
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR350152
- Product name
- Diethyl2-Propylimidazole-4,5-dicarboxylate
- Packaging
- 25g
- Price
- $174
- Updated
- 2021/12/16
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Diethyl 2-propylImidazoledicarbonate Chemical Properties,Usage,Production
Uses
Diethyl 2-propylImidazoledicarbonate is an intermediate in the synthesis of Olmesartan Medoxomil.
Chemical Properties
Light Yellow Solid
Uses
An intermediate in the synthesis of Olmesartan Medoxomil. (O550000)
Synthesis
58954-23-7
64-17-5
144689-94-1
General procedure for the synthesis of diethyl 2-propyl-4,5-imidazoledicarboxylate from 2-propyl-1H-imidazole-4,5-dicarboxylic acid and ethanol: 48 mmol of 2-n-propylimidazole-4,5-dicarboxylic acid (synthesized in Example 3) was added to a four-necked flask with 152 mL of ethanol. 20.22 g (165 mmol) of thionyl chloride was added slowly dropwise at liquid temperature over 1 hour and 40 minutes. Subsequently 0.91 g (51 mmol) of water was added and the reaction solution was cooled to room temperature. The reaction mixture was heated to reflux for 5 hours (liquid temperature: 74 °C to room temperature). Upon completion of the reaction, the precipitated inorganic salt was removed by filtration. The filtrate was concentrated and partitioned for extraction by adding 50 mL of ethyl acetate and 60 mL of saturated aqueous sodium bicarbonate. After adjusting the pH of the aqueous layer to 7, 20 mL of ethyl acetate was added. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the crude product of diethyl 2-propyl-4,5-imidazoledicarboxylate. To the crude product, 13.06 g of ethyl acetate and 1.07 g of ethanol were added, concentrated to a product weight of 14.5 g and crystallized. After filtration, it was dried under vacuum at 50°C to obtain diethyl 2-propyl-4,5-imidazoledicarboxylate. The first to third crystals were obtained sequentially by recrystallizing the mother liquor and repeating the recrystallization process according to the same method as in Example 1. By HPLC analysis, the yield was 9.50 g (77%) and the HPLC purity was 99.7% for the first crystal, 99.7% for the second crystal and 99.0% for the third crystal, respectively.
References
[1] Organic Preparations and Procedures International, 2006, vol. 38, # 4, p. 410 - 412
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 323 - 338
[3] Patent: JP5688696, 2015, B2. Location in patent: Paragraph 0097
Diethyl 2-propylImidazoledicarbonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diethyl 2-propylImidazoledicarbonate manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Diethyl 2-propylImidazoledicarbonate 144689-94-1
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000kg
- Release date
- 2021-11-19
Henan Aochuang Chemical Co.,Ltd.
- Product
- Diethyl 2-propylImidazoledicarbonate 144689-94-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- Olmesartan Medoxomil Impurity 27 144689-94-1
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-14
144689-94-1, Diethyl 2-propylImidazoledicarbonateRelated Search:
2-Propyl-1H-imidazole-4,5-dicarboxy acid
OlMesartan Lactone IMpurity
1-(4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazol-5-yl)ethanone
4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester
OlMesartan Ethyl Ester IMpurity
3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one
Olmesartan medoxomil impurity I
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate
Trityl olMesartan MedoxoMil iMpurity II
OlMesartan Methyl Ester
OlMesartan interMediate iMpurity II
OlMesartan MedoxoMil Butyl IMpurity
Olmesartan Impurity 12
5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole
4,5-Dimethyl-1,3-dioxol-2-one
4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid
Olmesartan
Olmesartan Impurity 10