Mono-tert-butyl succinate
- Product Name
- Mono-tert-butyl succinate
- CAS No.
- 15026-17-2
- Chemical Name
- Mono-tert-butyl succinate
- Synonyms
- 4-Tert-butoxy-4-oxobutanoic acid;MONO-TERT-BUTYL SUCCINATE;tert-Butyl hydrogen succinate;Succiniccidono-tert-butylster;MONO-TERT-BUTYL SUCCINATE 97％;mono-tert-Butyl succinate ,97%;4-Tert-Butoxy-4-OxobutanoicAci;mono-tert-Butyl succinate;SUCCINIC ACID MONO-TERT-BUTYL ESTER;Butanedioic acid, 1-(1,1-diMethylethyl) ester
- CBNumber
- CB0724603
- Molecular Formula
- C8H14O4
- Formula Weight
- 174.19
- MOL File
- 15026-17-2.mol
Mono-tert-butyl succinate Property
- Melting point:
- 51-54 °C(lit.)
- Boiling point:
- 92°C/1.5mmHg(lit.)
- Density
- 1.097±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Sparingly)
- pka
- 4.46±0.17(Predicted)
- form
- Solid
- color
- Yellow-brown
- Water Solubility
- Slightly soluble in water.
- InChIKey
- PCOCFIOYWNCGBM-UHFFFAOYSA-N
- CAS DataBase Reference
- 15026-17-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 547352
- Product name
- mono-tert-Butyl succinate
- Purity
- 97%
- Packaging
- 5g
- Price
- $226
- Updated
- 2025/07/31
- Product number
- M3033
- Product name
- Mono-tert-butyl Succinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- M3033
- Product name
- Mono-tert-butyl Succinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- M525035
- Product name
- Mono-tert-butyl Succinate
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 39720
- Product name
- Mono-tert-butylsuccinate,99%(GC)
- Purity
- 99%(GC)
- Packaging
- 25G
- Price
- $79.8
- Updated
- 2021/12/16
Mono-tert-butyl succinate Chemical Properties,Usage,Production
Uses
Mono-tert-butyl Succinate is a reagent used for the synthesis of fluorinated β2- and β3-amino acids, an inhibitor of α-chymotrypsin.
Synthesis Reference(s)
Tetrahedron Letters, 32, p. 4239, 1991 DOI: 10.1016/S0040-4039(00)92137-3
General Description
mono-tert-Butyl succinate can be prepared by refluxing a mixture of succinic anhydride and N-hydroxyl succinimide in the presence of dimethylaminopyridine and triethylamine in tert-butanol and toluene.
Synthesis
108-30-5
75-65-0
15026-17-2
Tert-butanol (10 mL) was added to a solution of toluene (100 mL) containing succinic anhydride (6.04 g, 60.40 mmol), N-hydroxysuccinimide (2.53 g, 22.01 mmol) and 4-dimethylaminopyridine (DMAP, 0.88 g, 7.23 mmol). The reaction mixture was heated under reflux conditions for 48 hours. Upon completion of the reaction, it was cooled to room temperature and two layers (brown oil and a clarified colorless solution) were observed to form in the reaction vessel. The crude product solution was diluted with ethyl acetate (EtOAc, 50 mL) and washed sequentially with 10% aqueous citric acid (2 x 50 mL) and saturated saline. The organic layer was dried over anhydrous sodium sulfate (Na2SO4) and the solvent was evaporated under reduced pressure. The crude product was recrystallized with a solvent mixture of ethyl ether/petroleum ether (1:3, 25 mL) to obtain mono-tert-butyl succinate in quantitative yield.
References
[1] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 2428 - 2441
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10460 - 10474
[3] Journal of Organic Chemistry, 2003, vol. 68, # 17, p. 6679 - 6684
[4] Organic Letters, 2006, vol. 8, # 4, p. 713 - 716
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 6, p. 1643 - 1647
Mono-tert-butyl succinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Mono-tert-butyl succinate manufacturers
- Product
- Mono-tert-butyl succinate 15026-17-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19
- Product
- Mono-tert-butyl succinate 15026-17-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19