15(S)-HETE

Product Name: 15(S)-HETE
CAS No.: 54845-95-3
Chemical Name: 15(S)-HETE
Synonyms: C04742;AL12959;AL 12959;AL-12959;Icomucret;15(S)-HETE;(S)-15-HETE;JSFATNQSLKRBCI-VAEKSGALSA-N;15(S)-HETE MaxSpec Standard;15(S)-HETE Lipid Maps MS Standard
CBNumber: CB0724870
Molecular Formula: C20H32O3
Formula Weight: 320.47
MOL File: 54845-95-3.mol

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15(S)-HETE Property

Boiling point:: 487.7±45.0 °C(Predicted)
Density: 0.984±0.06 g/cm3(Predicted)
Flash point:: 14℃
storage temp.: -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka: 4.75±0.10(Predicted)
form: Liquid.
BRN: 2470466

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Safety

Hazard Codes: F,Xi
Risk Statements: 11-36/37/38
Safety Statements: 7-16-26-36
RIDADR: UN 1170 3/PG 2
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 34720
Product name: 15(S)-HETE
Purity: ≥98%
Packaging: 25μg
Price: $39
Updated: 2024/03/01

Cayman Chemical

Product number: 10007251
Product name: 15(S)-HETE MaxSpec? Standard
Purity: ≥95%
Packaging: 100μg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 34720
Product name: 15(S)-HETE
Purity: ≥98%
Packaging: 50μg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 34720
Product name: 15(S)-HETE
Purity: ≥98%
Packaging: 100μg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 34720
Product name: 15(S)-HETE
Purity: ≥98%
Packaging: 500μg
Price: $566
Updated: 2024/03/01

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15(S)-HETE Chemical Properties,Usage,Production

Description

15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis.

Uses

15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis.

Uses

15(S)-HETE is an arachidonic acid metabolite with immunosuppressive activity.

Definition

ChEBI: An optically active form of 15-HETE having 15(S)-configuration..

General Description

15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).

Biochem/physiol Actions

Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.

15(S)-HETE Preparation Products And Raw materials

Raw materials

Preparation Products

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15(S)-HETE Suppliers

China 33 Germany 2 India 1 Japan 1 Switzerland 1 United Kingdom 2 United States 9 Global 49

Shanghai Boyle Chemical Co., Ltd.

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Yichang Zhongyitai Trading Co., Ltd.

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Sigma-Aldrich

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Alfa Chemistry

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Shanghai Hongye Biotechnology Co. Ltd

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TargetMol Chemicals Inc.

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Alfa Chemistry

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Taizhou Nanfeng Pharmaceutical Research Institute

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54845-95-3, 15(S)-HETERelated Search:

(±)-5-HETE, (±)-(6E,8Z,11Z,14Z)-5-Hydroxyeicosatetraenoic acid solution dendrotoxin K 5(S)-HETE 15(S)-HETE SOLUTION 15(S)-HETE ETHANOLAMIDE 15(R)-HETE 15(S)-HETE LIPID MAPS 15(S)-HETE-BIOTIN 15(S)-HPETE 15(S)-HPETE, [3H] 15(S)-HETE-D8 15(S)-HETE [3H] 15(S)-HETE 15(S)-HPETE [1-14C] 15(S)-HETE [1-14C] 15-HETE-[5,6,8,9,11,12,14,15-3H(N)]-

(15s,5z,8z,11z,13e)-15-hydroxyeicosatetraenoic acid

(5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid

Icomucret

(5Z,8Z,11Z,13E,15S)-15-Hydroxy-5,8,11,13-icosatetraenoic acid

(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate

(15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate

C04742

15(S)-HETE Lipid Maps MS Standard

(S)-15-HETE

JSFATNQSLKRBCI-VAEKSGALSA-N

15(S)-HYDROXY-(5Z,8Z,11Z,13E)-EICOSATETRAENOIC ACID

15(S)-HYDROXYEICOSA-5Z,8Z,11Z,13E-TETRAENOIC ACID

15(S)-HETE

15(S)-HETE MaxSpec Standard

5,8,11,13-Eicosatetraenoic acid, 15-hydroxy-, (5Z,8Z,11Z,13E,15S)-

AL 12959

AL12959

AL-12959

54845-95-3

Polyunsaturated

Unsaturated fatty acids and derivatives

Biochemicals and Reagents

BioChemical

Fatty Acids

Lipids

Hydroxy fatty acids