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Mometasone furoate

Product Name
Mometasone furoate
CAS No.
83919-23-7
Chemical Name
Mometasone furoate
Synonyms
NASONEX;Mometason Furoate;MOMETASONE 17-FUROATE;(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-pregna-1,4-diene-3,20-dione;Ecural;ElocoM;EloMet;Monovo;AsManex;SCH-32088
CBNumber
CB0725569
Molecular Formula
C27H30Cl2O6
Formula Weight
521.43
MOL File
83919-23-7.mol
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Mometasone furoate Property

Melting point:
218-220°C
alpha 
D26 +58.3° (dioxane)
Boiling point:
655.5±55.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
13.02±0.70(Predicted)
color 
white to off-white
optical activity
[α]/D +50 to +60°, c = 0.5 in methanol
InChIKey
WOFMFGQZHJDGCX-ZULDAHANSA-N
SMILES
C[C@]12C[C@H](OC(=O)C3=CC=CO3)C3([C@](CCC4[C@]3(C)C=CC(=O)C=4)([H])[C@]1([H])C[C@@H](C)[C@]2(OC(=O)C1OC=CC=1)C(=O)CCl)Cl |&1:1,3,13,17,25,28,30,r|
CAS DataBase Reference
83919-23-7(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
29372290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M4074
Product name
Mometasone furoate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$82.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1445470
Product name
Mometasone furoate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
21365
Product name
Mometasone Furoate
Purity
≥98%
Packaging
25mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21365
Product name
Mometasone Furoate
Purity
≥98%
Packaging
50mg
Price
$61
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1400
Product name
Mometasone Furoate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$116
Updated
2024/03/01
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Mometasone furoate Chemical Properties,Usage,Production

Description

Mometasone furoate is a topical steroidal antiinflammatory useful in the treatment of corticosteroid-responsive dermatoses. As a steroidal antiinflammatory of grade II potency, mometasone furoate is characterized by a once-daily dose regimen and a relatively wide safety margin.

Chemical Properties

White-to-Off-White Solid

Originator

Schering-Plough (USA)

Uses

Mometasone furoate is a deuterated topical corticosteroid used as an anti-inflammatory. Mometasone furoate has been used to study its effect on Leishmania major amastigotes. It could as labeled Mometasone, intended for use as an internal standard for the quantification of Mometasone by GC- or LC-mass spectrometry. Formulations containing mometasone furoate have been used in the treatment of allergic rhinitis, atopic dermatitis, and asthma. Intranasal administration of mometasone furoate (1 μg/nostril) reduces the frequency of sneezing and nasal rubbing in a rat model of histamine-induced allergic rhinitis. Topical application of mometasone furoate reduces croton oil-induced ear edema in mice (ED50 = 0.31 μg/ml).

Definition

ChEBI: Mometasone furoate is a 2-furoate ester, a steroid ester, an 11beta-hydroxy steroid, a 20-oxo steroid, an organochlorine compound and a 3-oxo-Delta(1),Delta(4)-steroid. It has a role as an anti-inflammatory drug and an anti-allergic agent. It is functionally related to a mometasone.

Manufacturing Process

METHOD I (Patent U.S. 4,472,393)
A. 21-Chloro-9β,11β-epoxy-17α-hydroxy-16α-methyl-1,4-pregnadiene-3,20- dione
Prepare a solution of 5.0 g. of 9β,11β-epoxy-17α,21-dihydroxy-16α-methyl- 1,4-pregnadiene-3,20-dione in 20 ml of dry pyridine. Cool on an ice bath; to the stirred solution under nitrogen, add dropwise 1.1 ml of mesyl chloride. Remove the ice bath and continue stirring at room temperature for 30 min. Add 2.0 g of lithium chloride and continue stirring for a further 150 min. Add to a mixture of 150 ml ethyl acetate and 100 ml distilled water. Wash the organic phase with dilute 3% aqueous hydrochloric acid, then saturated aqueous sodium chloride solution and finally saturated sodium bicarbonate solution. Dry the organic phase over magnesium sulfate, filter and remove the solvent to give 4.62 g of 21-chloro-9β,11β-epoxy-17α-hydroxy-16α-methyl- 1,4-pregnadiene-3,20-dione.
B. 21-Chloro-9β,11β-epoxy-17α-hydroxy-16α-methyl-1,4-pregnadiene-3,20- dione 17-(2'-furoate)
Prepare under argon a solution of 8 g of 4-dimethylaminopyridine in 250 ml of dry methylene chloride. Cool on an ice bath and add to the stirred solution 6.0 ml of 2-furoyl chloride. Remove from the ice bath, allow the temperature to rise to room temperature and then add 11.5 g of the 21-chloro-9β,11β-epoxy- 17α-hydroxy-16α-methyl-1,4-pregnadiene-3,20-dione. After 24 hours add 500 ml of ethyl acetate saturated with water. Filter off the precipitate and then evaporate off the solvent to give the crude 21-chloro-9β,11β-epoxy-17α- hydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 17-(2'-furoate).
C. 9α,21-Dichloro-11β,17α-hydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 17-(2'-furoate)
To the crude 21-chloro-9β,11β-epoxy-17α-hydroxy-16α-methyl-1,4- pregnadiene-3,20-dione 17-(2'-furoate) add 50 ml of glacial acetic acid, then add a solution of 3.5 g of anhydrous hydrogen chloride in 125 ml of glacial acetic acid. Stir for 15 minutes and then quench with 500 ml of distilled water. Filter off the solids, recrystallise from methanol:water, dry for 24 hours under vacuum to give 12.6 g 9α,21-dichloro-11β,17α-hydroxy-16α-methyl-1,4- pregnadiene-3,20-dione 17-(2'-furoate) (yield 83% of theory).
Prepare under nitrogen a solution of 1.80 g of 21-chloro-17α-hydroxy-16α- methyl-1,4,9(11)-pregnatriene-3,20-dione 17-(2'-furoate). Add, with stirring, a solution of 1.15 ml of 70% perchloric acid in 2.53 ml of distilled water, and immediately thereafter 604 mg of 1,3-dichloro-5,5-dimethylhydantoin. Stir the reaction mixture for twenty minutes and then raise the temperature to ambient temperature. Monitor the consumption of starting material by thin layer chromatography of aliquots using chloroform:1,3-dichloro-5,5- dimethylhydantoinyl acetate (9:1) and hexane:ethyl acetate (1:1). When the starting material is consumed, pour the reaction mixture into 500 ml of distilled water containing the 1,3-dichloro-5,5-dimethylhydantoin and 7 g of sodium bisulphite. Add sodium chloride until the solution is saturated. Filter the precipitated solid, wash and dry at 50°C under vacuum. Purify the resulting crude product by preparative chromatography on 1000 micron silica gel plates using chloroform: ethyl acetate (19:1). Elute the desired band with ethyl acetate, filter the eluate and evaporate at room temperature to give crude product (1.3 g). Recrystallize the product by dissolving in refluxing methylene chloride, filtering and then replacing the methylene chloride at reflux with methanol and then the methanol with distilled water. Cool the suspension to room temperature, filter and dry under vacuum at 50°C to give the pure pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-((2- furanylcarbonyl)oxy)-11-hydroxy-16-methyl-, (11β-,16α)-.
METHOD II
The present invention (Patent U.S. 6,177,560) refers to a new process for the preparation of mometasone furoate carried out by esterifiication of the 17 hydroxy group of mometasone without prior protection of the 11 hydroxy group. Mometasone (30 g) was suspended in methylene chloride (300 ml) and the resulting suspension was cooled to 0-5°C. At this temperature triethylamine (57 ml) was added. 2-Furoyl chloride (24 ml) was then added slowly. The mixture was then stirred at 8-12°C until the level of mometasone present was lower than 0.2% by HPLC. The reaction solution was then cooled to between -5-5°C and water (120 ml) was added with stirring. After stirring for 1 hour at 10-15°C the mixture was cooled to between 0-5°C and concentrated hydrochloric acid was added to adjust the pH of the aqueous layer between 1 and 2.
The phases were separated and the aqueous layer was extracted with methylene chloride (60 ml). To the combined organic layers concentrated hydrochloric acid (90 ml) and acetic acid (30 ml) was added at a temperature 15-25°C. Then the two phase reaction mixture was stirred until less than 0.1% of the side products remained as monitored by HPLC. The reaction mixture was cooled to 0-5°C and water (120 ml) was added. The lower organic layer was separated, water (120 ml) and 8 N aqueous sodium hydroxide solution (about 30 ml) were added to adjust the pH to between 5 and 6. After stirring for 2 hours the organic layer was separated and washed with water (120 ml). The organic solution [containing the mometasone 17-(2- furoate)] was concentrated by distillation to a volume of 120 ml. Further methanol (120 ml) was added and the mixture was concentrated to 120 ml. This procedure was repeated twice more. The reaction mixture was slowly cooled to 0-5°C and stirred for 2 hours. The crude mometasone 17-(2- furoate) was then filtered off and washed with cold methanol.
Purification of mometasone 17-(2-furoate)
The wet cake was dissolved in acetone (395 ml) and charcoal (3 g) was added. After 24 hours, the charcoal was filtered off and washed with acetone (90 ml). Charcoal (3 g) was added to the solution and the solution stirred for at least 24 hours at between 15-25°C. The charcoal was then filtered off and washed with acetone (75 ml). The solution was concentrated by distillation to a volume of 120 ml. During this concentration the mometasone 17-(2-furoate) started to crystallise. Methanol (120 ml) was added and the solution was again concentrated to 120 ml. This procedure was repeated twice. The suspension was cooled slowly to 0-5°C and stirred for about 2 hours at this temperature. The pure mometasone 17-(2-furoate) was then filtered off and washed with cold methanol. The product was dried at 60-70°C. A yield of 29.92 g was obtained.

brand name

Asmanex (Schering);Elocon (Schering).

Therapeutic Function

Glucocorticoid

Biological Functions

Mometasone furoate has strong local anti-inflammatory activity equivalent to that of fluticasone propionate. It has a quick onset of action relative to the other inhaled/intranasal steroids with the least systemic availability and, consequently, the fewest systemic side effects.

General Description

Mometasone furoate (Asmanex,Nasonex) undergoes extensive metabolism to multiplemetabolites. No major metabolites are detectable in humanplasma after oral administration, but the 6β-hydroxy metaboliteis detectable by use of human liver microsomes. Thismetabolite is formed via the CYP3A4 pathway.

General Description

Mometasone furoate,9,21-dichloro-17α-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione (Elocon), is a highpotencyGC available in cream, lotion, or ointment formulationsfor topical use. In addition, mometasone furoatemonohydrate is formulated for treating allergic rhinitis andasthma.

Biochem/physiol Actions

Mometasone furoate is a 17-heterocyclic intranasal corticosteroid. It is effectively used as a first-line daily intranasal therapeutic for allergic rhinitis and nasal polyposis. Mometasone furoate is also used as an adjunct to anti-bacterials for treating acute rhinosinusitis. In addition, it relieves the symptoms of asthma in both adults and adolescents by exhibiting a broad spectrum of anti-inflammatory properties.

Mechanism of action

Mometasone furoate is the most recent glucocorticoid to be developed and commercialized. It has a number of unique functional groups that confer enhanced glucocorticoid activity as well as pharmacokinetic advantages. The combination of the C-21 chloro and the furoic acid ester at C-17 results in the highest glucocorticoid receptor affinity of any topical corticosteroid. The 16α- methyl decreases the mineralocorticoid effects, and the 9α-chloro group increases both glucocorticoid and mineralocorticoid activities. Inhaled mometasone furoate acts locally as an anti-inflammatory treatment for asthma and has the least systemic bioavailability of all the inhaled glucocorticoids (<1%).

Clinical Use

Mometasone furoate was originally marketed as a topically applied corticosteroid, but because of its low systemic bioavailability, it was found to be more useful in the treatment of allergic disorders and lung diseases (107).

Metabolism

It is extensively metabolized, with 6β-hydroxymometasone and 21-hydroxymometasone being found among the metabolites. Inhaled mometasone furoate in mainly excreted in the feces (~74%) as metabolites and only minimally excreted in the urine (~8%). It has a relatively long half-life in the lung and is administered once daily, usually in the evening.

Mometasone furoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Mometasone furoate Suppliers

Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 17825480238
Fax
QQ 3008233717
Email
3008233717@qq.com
Country
China
ProdList
9919
Advantage
12
Wuhan Zenuo Biopharmaceutical Technology Co., Ltd
Tel
027-87781970 15172508891
Email
1505560767@qq.com
Country
China
ProdList
133
Advantage
58
Wuhan DingCheng Biochemical Co.Ltd
Tel
13545255233 13545255233
Email
2851686513@qq.com
Country
China
ProdList
913
Advantage
58
Hunan Jiuwei Biopharmaceutical Co., Ltd
Tel
19176660800
Email
alexybw@hnjwpharma.com
Country
China
ProdList
23
Advantage
58
Shandong Risen-Sun Pharmaceutical Co., Ltd
Tel
0538-8923066 15621883869
Email
172688504@qq.com
Country
China
ProdList
64
Advantage
58
Wuhan Juchengyuan Biotechnology Co., Ltd
Tel
400-0276007 18062142210
Email
804180422@qq.com
Country
China
ProdList
140
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
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View Lastest Price from Mometasone furoate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Mometasone furoate 83919-23-7
Price
US $0.00/Kg/Bag
Min. Order
10g
Purity
97%-102%; USP
Supply Ability
10kg
Release date
2021-08-20
Hebei Yanxi Chemical Co., Ltd.
Product
Mometasone furoate 83919-23-7
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-10-23
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Mometasone furoate 83919-23-7
Price
US $600.00-3600.00/gram
Min. Order
100gram
Purity
99% HPLC
Supply Ability
20 tons
Release date
2022-10-21

83919-23-7, Mometasone furoateRelated Search:


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  • (11BETA,16ALPHA)-9,21-DICHLORO-17-[(2-FURANYLCARBONYL)OXY]-11-HYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
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  • (+)-9,21-Dichloro-11',17'-dihydroxy-16-alpha-methyl-1,4-pregnadiene-3,20-dione-17-(2-furoate)
  • Sch-32088, Elocon, Nasonex
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  • C27H30Cl2O6
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