ChemicalBook > CAS DataBase List > 4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE

4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE

Product Name: 4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE
CAS No.: 473528-88-0
Chemical Name: 4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE
Synonyms: AKOS B007395;ART-CHEM-BB B007395;4-Bromo-1-methylpyrazole-5-carbaldehyd;4-Bromo-2-methylpyrazole-3-carbaldehyde;4-Bromo-1-methylpyrazole-5-carbaldehyde;4-BROMO-1-METHYLPYRAZOLE-5-CARBOXALDEHYDE;4-Bromo-1-methyl-1H-pyrazol-5-carbaldehyde;4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE;4-BROMO-2-METHYL-2 H-PYRAZOLE-3-CARBALDEHYDE;1H-Pyrazole-5-carboxaldehyde, 4-bromo-1-methyl-
CBNumber: CB0730198
Molecular Formula: C5H5BrN2O
Formula Weight: 189.01
MOL File: 473528-88-0.mol

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4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE Property

Melting point:: 102-103°C
Boiling point:: 275.2±20.0 °C(Predicted)
Density: 1.73±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.48±0.10(Predicted)
Sensitive: Air Sensitive
CAS DataBase Reference: 473528-88-0

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 2933119000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B694695
Product name: 4-Bromo-1-methylpyrazole-5-carbaldehyde
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B12945
Product name: 4-Bromo-1-methyl-1H-pyrazole-5-carboxaldehyde
Purity: 95%
Packaging: 1g
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H15-9-33
Product name: 4-Bromo-1-methyl-1H-pyrazole-5-carboxaldehyde
Packaging: 1g
Price: $138
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B12945
Product name: 4-Bromo-1-methyl-1H-pyrazole-5-carboxaldehyde
Purity: 95%
Packaging: 5g
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB76748
Product name: 4-Bromo-2-methyl-2H-pyrazole-3-carbaldehyde
Packaging: 1g
Price: $260
Updated: 2021/12/16

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4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE Chemical Properties,Usage,Production

Synthesis

27258-33-9

473528-88-0

General procedure for the synthesis of 1-methylpyrazole-5-carboxaldehyde using 1-methyl-1H-pyrazole-5-carboxaldehyde as starting material: a solution of N,N-dimethylformamide (DMF, 5 mL) of N-bromosuccinimide (NBS, 1.62 g, 9.09 mmol) was slowly added dropwise to a solution of 1-methyl-1H-pyrazole-5-carboxaldehyde (1.0 g, 9.09 mmol) solution in DMF (8 mL). The reaction mixture was stirred at room temperature overnight. Subsequently, 1N sodium hydroxide solution (9.1 mL) was added and stirring was continued for 10 min. The reaction solution was diluted with water (100 mL) and extracted with ethyl acetate (EtOAc, 30 mL x 3). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give an orange solid product (1.57 g, 92% yield). Liquid phase mass spectrometry (LRMS) detection showed m/z (M+H) of 187.9 and the measured value was 188.0.

References

[1] Patent: WO2014/81619, 2014, A1. Location in patent: Page/Page column 47
[2] Chemistry - A European Journal, 2018, vol. 24, # 38, p. 9530 - 9534

4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE Suppliers

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473528-88-0, 4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDERelated Search:

4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE 4-BROMO-1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 4-BROMO-1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBONYL CHLORIDE 4-BROMO-1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE,4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE,4-BROMO-2-METHYL-2 H-PYRAZOLE-3-CARBALDEHYDE 4-Bromo-1-methylpyrazole 4-BROMO-1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 4-bromo-1-methylpyrazole-3-carboxy acid METHYL 4-BROMO-1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLATE methyl 4-bromo-1-methyl-1H-pyrazole-5-carboxylate 4-BROMO-2-ETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 4-BROMO-1-(4-CHLOROBENZYL)-1H-PYRAZOLE-5-CARBALDEHYDE 4-BROMO-2-METHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID HYDRAZIDE 4-BROMO-N-METHYL-1-(4-METHYLPHENYL)-1H-PYRAZOLE-5-CARBOXAMIDE 4-BROMO-2-METHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID 4-BROMO-2,5-DIMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID HYDRAZIDE 4-BROMO-1-(4-METHYLBENZYL)-1H-PYRAZOLE-5-CARBOXALDEHYDE AKOS B000957

AKOS B007395

4-BROMO-1-METHYLPYRAZOLE-5-CARBOXALDEHYDE

4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE

4-BROMO-2-METHYL-2 H-PYRAZOLE-3-CARBALDEHYDE

ART-CHEM-BB B007395

4-Bromo-1-methylpyrazole-5-carbaldehyde

4-Bromo-2-methylpyrazole-3-carbaldehyde

4-BroMo-1-Methyl-1H-pyrazole-5-carboxaldehyde, 97%

1H-Pyrazole-5-carboxaldehyde, 4-bromo-1-methyl-

4-Bromo-1-methyl-1H-pyrazole-5-carboxaldehyde,97%

4-Bromo-1-methylpyrazole-5-carbaldehyd

4-Bromo-1-methyl-1H-pyrazol-5-carbaldehyde

473528-88-0