7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO-

Product Name: 7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO-
CAS No.: 31170-78-2
Chemical Name: 7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO-
Synonyms: 7H-Cyclopenta[b]pyridin-5-one;7H-cyclopenta[b]pyridin-7-one;5H-Cyclopenta[b]pyridin-7(6H);5,6-Dihydro-[1]pyrindin-7-one;5H-CYCLOPENTATBPYRIDIN-7(6H)-ONE;5H-cyclopenta[b]pyridin-7(6H)-one;5H,6H,7H-cyclopenta[b]pyridin-7-one;5,6-Dihydro-7H-cyclopenta[b]pyridin-7-one;7H-cyclopenta[b]pyridin-5-one,6,7-dihydro-;7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO-
CBNumber: CB0735294
Molecular Formula: C8H7NO
Formula Weight: 133.15
MOL File: 31170-78-2.mol

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7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO- Property

Melting point:: 118-120 °C
Boiling point:: 130-150 °C(Press: 0.1 Torr)
Density: 1.230±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 3.50±0.20(Predicted)
Appearance: Gray to dark gray Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D448805
Product name: 5,6-Dihydro-7H-cyclopenta[b]pyridin-7-one
Packaging: 100mg
Price: $125
Updated: 2021/12/16

TRC

Product number: D448805
Product name: 5,6-Dihydro-7H-cyclopenta[b]pyridin-7-one
Packaging: 1g
Price: $850
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144364
Product name: 5H-Cyclopenta[b]pyridin-7(6H)-one
Packaging: 2g
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-W003423
Product name: 5H-Cyclopenta[b]pyridin-7(6H)-one
Purity: 99.43%
Packaging: 250mg
Price: $51
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144364
Product name: 5H-Cyclopenta[b]pyridin-7(6H)-one
Packaging: 250mg
Price: $100
Updated: 2021/12/16

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7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO- Chemical Properties,Usage,Production

Uses

5,6-Dihydro-7H-cyclopenta[b]pyridin-7-one, is an intermediate for the synthesis of pharmaceutical and biological compounds. It can be used for synthesis of new propargylated 1-pyrindane derivatives as Rasagiline (R126000) analogues, used as an antiparkinsonian agent.

Synthesis

74701-35-2

31170-78-2

General procedure for the synthesis of 5,6-dihydro-7H-cyclopenta[b]pyridin-7-one from the compound (CAS: 74701-35-2): 5-benzylidene-6,7-dihydro-5H-[1]pyrazine (12.18 g, 58.8 mmol) was dissolved in 200 mL of mixed solvent of MeOH:CH2Cl2 (1:1), and the ozonolysis reaction was performed at 7 psi and 1.5 amperes for the ozonolysis reaction. Upon completion of the reaction, the reaction mixture was quenched with thiourea, filtered and concentrated. The product was purified by column chromatography using hexane:EtOAc (4:1) as eluent to afford 5.96 g (76% yield) of 5,6-dihydro-7H-cyclopenta[b]pyridin-7-one. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 2.75-2.82 (m, 2H), 3.15-3.22 (m, 2H), 7.47 (q, J = 4.40, 3.52 Hz, 1H), 7.91 (d, J = 8.79 Hz, 1H), 8.79 (d, J = 5.28 Hz, 1H).

References

[1] Patent: US2008/255239, 2008, A1. Location in patent: Page/Page column 32
[2] Journal of Organic Chemistry, 1984, vol. 49, # 12, p. 2208 - 2212
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 3, p. 392 - 395

7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO- Preparation Products And Raw materials

Raw materials

Preparation Products

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7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO- Suppliers

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View Lastest Price from 7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO- manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO- 31170-78-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO- 31170-78-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO- 31170-78-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

31170-78-2, 7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO-Related Search:

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7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO-

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5,6-Dihydro-7H-cyclopenta[b]pyridin-7-one

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7H-cyclopenta[b]pyridin-7-one

7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO- ISO 9001：2015 REACH

5H-CYCLOPENTATBPYRIDIN-7(6H)-ONE

31170-78-2

Pyridine Derivertives