ICI 89406

Product Name: ICI 89406
CAS No.: 53671-71-9
Chemical Name: ICI 89406
Synonyms: C025716;ICI 89406;ICI 89406, 10 mM in DMSO;N-[2-[3-(2-CYANOPHENOXY)-2-HYDROXYPROPYLAMINO]ETHYL]-N'-PHENYLUREA;1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea;Urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-;Adrenergic Receptor,Inhibitor,inhibit,ICI-89406,Beta Receptor,ICI 89406,ICI89406
CBNumber: CB0741961
Molecular Formula: C19H22N4O3
Formula Weight: 354.4
MOL File: 53671-71-9.mol

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ICI 89406 Property

Melting point:: 155-156 °C(Solv: acetonitrile (75-05-8))
Boiling point:: 575.0±50.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble in ethanol and to 100 mM in DMSO
form: Powder
pka: 12.29±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: I163890
Product name: ICI89406
Packaging: 10mg
Price: $140
Updated: 2021/12/16

ApexBio Technology

Product number: B6464
Product name: ICI89406
Packaging: 10mg
Price: $219
Updated: 2021/12/16

ApexBio Technology

Product number: B6464
Product name: ICI89406
Packaging: 50mg
Price: $896
Updated: 2021/12/16

Crysdot

Product number: CD12063829
Product name: ICI89406
Purity: 97%
Packaging: 1g
Price: $990
Updated: 2021/12/16

Crysdot

Product number: CD12063829
Product name: ICI89406
Purity: 97%
Packaging: 250mg
Price: $396
Updated: 2021/12/16

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ICI 89406 Chemical Properties,Usage,Production

Uses

ICI 89406 is beta-1-selective antagonist.

Definition

ChEBI: 1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea is a member of ureas.

Biological Activity

β -adrenergic antagonist and low efficacy partial agonist; does not affect resting cardiac parameters.

in vivo

Animal Model:	Rats^[2].
Dosage:	0.6, 5 or 50 mg/kg.
Administration:	Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis).
Result:	Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%.

ICI 89406 Preparation Products And Raw materials

Raw materials

Preparation Products

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ICI 89406 Suppliers

CHINA 15 Germany 1 United Kingdom 2 United States 6 USA 1 Global 25

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53671-71-9, ICI 89406Related Search:

2-Ethoxybenzonitrile Benzonitrile, 2-(2-hydroxyethoxy)- (9CI) 2-PROPOXYBENZONITRILE ICI 89406

N-[2-[3-(2-CYANOPHENOXY)-2-HYDROXYPROPYLAMINO]ETHYL]-N'-PHENYLUREA

ICI 89406

C025716

Urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-

1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea

Adrenergic Receptor,Inhibitor,inhibit,ICI-89406,Beta Receptor,ICI 89406,ICI89406

ICI 89406, 10 mM in DMSO

53671-71-9