6-HYDROXY-1,4-BENZODIOXANE
- Product Name
- 6-HYDROXY-1,4-BENZODIOXANE
- CAS No.
- 10288-72-9
- Chemical Name
- 6-HYDROXY-1,4-BENZODIOXANE
- Synonyms
- CHEMBRDG-BB 4003146;1,4-Benzodioxan-6-ol;6-Hydroxy-1,4-benzodioxan;6-Hydroxy-1.4-benxodioxane;6-HYDROXY-1,4-BENZODIOXANE;1,3-Dihydro-1,4-benzodioxin-6-ol;2,3-Dihydrobenzo[1,4]dioxin-6-ol;2,3-DIHYDRO-1,4-BENZODIOXIN-6-OL;1,4-Benzodioxin-6-ol,2,3-dihydro-;2,3-dihydrobenzo[b][1,4]dioxin-6-ol
- CBNumber
- CB0744533
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 10288-72-9.mol
6-HYDROXY-1,4-BENZODIOXANE Property
- Boiling point:
- 291℃
- Density
- 1.302
- Flash point:
- 130℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Dichloromethane, Ethyl Acetate
- pka
- 10.12±0.20(Predicted)
- form
- Oil
- color
- Brown
- InChI
- InChI=1S/C8H8O3/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-2,5,9H,3-4H2
- InChIKey
- DBPZCGJRCAALLW-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(O)C=C2OCC1
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H808475
- Product name
- 6-Hydroxy-1,4-benzodioxane
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 016635
- Product name
- 6-Hydroxy-1,4-benzodioxane
- Purity
- 94+%
- Packaging
- 500mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- OR916527
- Product name
- 2,3-Dihydrobenzo[b][1,4]dioxin-6-ol
- Purity
- 96%
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 016635
- Product name
- 6-Hydroxy-1,4-benzodioxane
- Purity
- 94+%
- Packaging
- 1g
- Price
- $137
- Updated
- 2021/12/16
- Product number
- 2H10-1-36
- Product name
- 2,3-Dihydro-1,4-benzodioxin-6-ol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $152
- Updated
- 2021/12/16
6-HYDROXY-1,4-BENZODIOXANE Chemical Properties,Usage,Production
Chemical Properties
Yellow Oil
Uses
6-Hydroxy-1,4-benzodioxane (cas# 10288-72-9) is a compound useful in organic synthesis.
Synthesis
29668-44-8
10288-72-9
General procedure for the synthesis of 6-hydroxy-1,4-benzodioxane from 1,4-benzodioxane-6-carboxaldehyde: To a solution of 2,3-dihydro-benzo[1,4]dioxine-6-carboxaldehyde (30.0 g, 183 mmol) in methylene chloride (500 mL) was added m-chloroperoxybenzoic acid (mCPBA, 37.85 g, 219 mmol). The suspension was heated to 50 °C and the reaction was carried out for 16 hours. Upon completion of the reaction, saturated sodium bicarbonate (NaHCO3) solution was added and the mixture was extracted with dichloromethane (CH2Cl2). The organic phases were combined, concentrated in vacuum, dissolved in methanol (MeOH) and 4 M sodium hydroxide (NaOH, 200 mL) solution was added. After 2 hours of reaction, the mixture was acidified with 4 M hydrochloric acid (HCl) and extracted with ethyl acetate (EtOAc). The organic phases were combined, washed sequentially with saturated sodium bicarbonate (NaHCO3) solution and brine, concentrated in vacuum and dissolved in dichloromethane (CH2Cl2). The solution was filtered to remove the precipitate. The resulting solution was stirred with saturated sodium bicarbonate (NaHCO3) solution for 1 h. The organic phase was separated, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated in vacuo to give 2,3-dihydro-benzo[1,4]dioxin-6-ol (26.92 g, 94% yield).
References
[1] Patent: US2005/209260, 2005, A1. Location in patent: Page/Page column 114
[2] Patent: US2007/49609, 2007, A1. Location in patent: Page/Page column 102
[3] Patent: WO2018/134254, 2018, A1. Location in patent: Page/Page column 68
[4] Chemistry and Biodiversity, 2010, vol. 7, # 4, p. 887 - 897
[5] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 6, p. 2051 - 2066
6-HYDROXY-1,4-BENZODIOXANE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-HYDROXY-1,4-BENZODIOXANE manufacturers
- Product
- 6-HYDROXY-1,4-BENZODIOXANE 10288-72-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 6-HYDROXY-1,4-BENZODIOXANE 10288-72-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25
- Product
- 6-HYDROXY-1,4-BENZODIOXANE 10288-72-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25