CYCLOCREATINE

Product Name: CYCLOCREATINE
CAS No.: 35404-50-3
Chemical Name: CYCLOCREATINE
Synonyms: CYCLOCREATINE;2-imino-1-imidazolinolinic acid;2-IMINO-1-IMIDAZOLIDINEACETIC ACID;1-Carboxymethyl-2-iminoimidazolidin;1-CARBOXYMETHYL-2-IMINOIMIDAZOLIDINE;(2-Iminoimidazolidin-1-yl)acetic acid;2-Imino-1-imidazolidineacetic acid 98%;2-(2-Iminoimidazolidin-1-yl)acetic acid;2-(2-iminoimidazolidine-1-yl)acetic acid;2-Amino-4,5-dihydro-1H-Imidazole-1-acetic Acid
CBNumber: CB0755285
Molecular Formula: C5H9N3O2
Formula Weight: 143.14
MOL File: 35404-50-3.mol

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CYCLOCREATINE Property

Melting point:: 322-326?C
storage temp.: -20°C Freezer
solubility: 1 M HCl: soluble25mg/mL, clear, colorless
form: Solid
color: White to Off-White
InChI: InChI=1S/C5H9N3O2/c6-5-7-1-2-8(5)3-4(9)10/h1-3H2,(H2,6,7)(H,9,10)
InChIKey: AMHZIUVRYRVYBA-UHFFFAOYSA-N
SMILES: C1(N)N(CC(O)=O)CCN=1
CAS DataBase Reference: 35404-50-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 2940000080
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 377627
Product name: 2-Imino-1-imidazolidineacetic acid
Purity: 98%
Packaging: 1g
Price: $131.1
Updated: 2025/07/31

Cayman Chemical

Product number: 20649
Product name: Cyclocreatine
Purity: ≥95%
Packaging: 500mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 20649
Product name: Cyclocreatine
Purity: ≥95%
Packaging: 1g
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 20649
Product name: Cyclocreatine
Packaging: 5g
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 20649
Product name: Cyclocreatine
Packaging: 10g
Price: $570
Updated: 2024/03/01

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CYCLOCREATINE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Cyclocreatine is used to regulate creatine biosynthesis by suppressing the level of arginine:glycine amidinotransferase in chick liver.

Uses

Can regulate creatine biosynthesis by suppressing the level of arginine:glycine amidinotransferase in chick liver

Biological Activity

Creatine analog th at protects tissues from ischemic damage; decreases the rate of ATP production via creatine kinase and reduces the proliferation of tumor cell lines th at are characterized by high levels of creatine kinase expression.

in vivo

Cyclocreatine (500 mg/kg, i.v., a single dose for 60 min) restores heart contractile function and shows markedly less myocardial cell injury when compared to the control (saline) group in the acute myocardial infarction (AMI) intact dog model^[1].
Cyclocreatine (0.28 mg/g, drink, supplementation daily from 10-week to 8 months) rescues microgliosis and clustering and moderates neurite dystrophy in TREM2^?/? 5XFAD mice^[2].
Cyclocreatine (40 mg, gavage, daily for 1 month) significantly reduces liver metastatic burden and affects prostate cancer progression in a model of liver metastasis of mice^[3].

Animal Model:	AMI-intact dog model^[1]
Dosage:	500 mg/kg
Administration:	i.v., a single dose for 60 min
Result:	Preserved 85% of pre-ischemic ATP level (loss of only 15%) and 97% of the CrP (loss of 3%) during ischemia, as well as immediately restored over 80% of contractile function during the 2 h of reperfusion in AMI-intact dog model.

Animal Model:	5XFAD and TREM2^?/? 5XFAD mice
Dosage:	0.28 mg/g
Administration:	Drinking water supplementation with cyclocreatine daily from 10-week to 8 months
Result:	Improved microglial metabolism and the protective response to Aβ plaques in TREM2-deficient 5XFAD mice.

CYCLOCREATINE Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLOCREATINE Suppliers

Canada 1 China 82 Germany 1 India 1 Switzerland 1 United Kingdom 9 United States 9 Global 104

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14917
Advantage: 59

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai MOF Chemical Tech Limited

Tel: 13661494087 18964793018
Fax: 86-021-51821718 QQ：2427604606
Email: sales@mof-chemicals.com
Country: China
ProdList: 293
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

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View Lastest Price from CYCLOCREATINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: CYCLOCREATINE 35404-50-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: CYCLOCREATINE 35404-50-3
Price: US $1066.20/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-03

35404-50-3, CYCLOCREATINERelated Search:

CYCLOCREATINE-2-14C Guanidineacetic acid Cyclocreatine-2-14C Creatine N,N-DIETHYL-GUANIDINE CYCLOCREATINE

CYCLOCREATINE

2-IMINO-1-IMIDAZOLIDINEACETIC ACID

1-CARBOXYMETHYL-2-IMINOIMIDAZOLIDINE

1-Carboxymethyl-2-iminoimidazolidin

2-Amino-4,5-dihydro-1H-Imidazole-1-acetic Acid

2-Imino-1-imidazolidineacetic acid 98%

2-(2-Iminoimidazolidin-1-yl)acetic acid

(2-Iminoimidazolidin-1-yl)acetic acid

Cyclocreatine, 1-Carboxymethyl-2-iminoimidazolidine

1H-Imidazole-1-aceticacid, 2-amino-4,5-dihydro-

CyclocreatineQ: What is Cyclocreatine Q: What is the CAS Number of Cyclocreatine Q: What is the storage condition of Cyclocreatine Q: What are the applications of Cyclocreatine

2-imino-1-imidazolinolinic acid

2-(2-iminoimidazolidine-1-yl)acetic acid

35404-50-3

C5H9N3O2

CARBOXYLIC ACID

BioChemical

Antitumor Agents

Cancer Research

Enzyme Inhibitors

Heterocyclic Compounds

Heterocycles

Inhibitors