ChemicalBook > CAS DataBase List > N-(4-Oxocyclohexyl)phthalimide

N-(4-Oxocyclohexyl)phthalimide

Product Name: N-(4-Oxocyclohexyl)phthalimide
CAS No.: 104618-32-8
Chemical Name: N-(4-Oxocyclohexyl)phthalimide
Synonyms: 4-Phthalamido Cyclohexanone;4-(PHTHALIMIDO)-CYCLOHEXANONE;4-(phthaliMide)-cyclohexanone;N-(4-Oxocyclohexyl)phthalimide;N-(4-Oxocyclohexyl)phthalimide>N-(4-Oxocyclohexyl)phthalimide;4-Phthalimidocyclohexanone yclohexanone;2-(4-Oxo-cyclohexyl)-isoindole-1,3-dione;2-(4-oxocyclohexyl)isoindoline-1,3-dione;2-(4-Oxocyclohexyl)-1H-isoindol-1,3(2H)-dione
CBNumber: CB0760692
Molecular Formula: C14H13NO3
Formula Weight: 243.26
MOL File: 104618-32-8.mol

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N-(4-Oxocyclohexyl)phthalimide Property

Melting point:: 142.0 to 146.0 °C
Boiling point:: 410.0±38.0 °C(Predicted)
Density: 1.357
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: -2.27±0.20(Predicted)
color: White to Almost white
InChI: InChI=1S/C14H13NO3/c16-10-7-5-9(6-8-10)15-13(17)11-3-1-2-4-12(11)14(15)18/h1-4,9H,5-8H2
InChIKey: PWUJQPNLEZZILN-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC=C2)C(=O)N1C1CCC(=O)CC1
CAS DataBase Reference: 104618-32-8

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Safety

HS Code: 2925.19.4200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: O0365
Product name: N-(4-Oxocyclohexyl)phthalimide
Purity: >98.0%(GC)(N)
Packaging: 5g
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: O0365
Product name: N-(4-Oxocyclohexyl)phthalimide
Purity: >98.0%(GC)(N)
Packaging: 25g
Price: $147
Updated: 2025/07/31

TRC

Product number: O849760
Product name: N-(4-Oxocyclohexyl)Phthalimide
Packaging: 5g
Price: $130
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 52621
Product name: N-(4-Oxocyclohexyl)Phthalimide
Packaging: 100g
Price: $1050
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0127090
Product name: N-(4-OXOCYCLOHEXYL)PHTHALIMIDE
Purity: 95.00%
Packaging: 25G
Price: $1255.86
Updated: 2021/12/16

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N-(4-Oxocyclohexyl)phthalimide Chemical Properties,Usage,Production

Uses

N-(4-Oxocyclohexyl) Phthalimide is an impurity of Pramipexol (P700755), a dopamine-D2-receptor agonist used in the early treatment of Parkinson''s disease and restless legs syndrome.

Synthesis

104618-31-7

104618-32-8

Example 1: Synthesis of 4-(phthalimido)cyclohexanone 4-(Phthalimido)cyclohexanol (146 g) was mixed with ethyl acetate (1000 mL), followed by the addition of sodium bromide (8 g) and 2,2,6,6-tetramethylpiperidin-1-oxyl radical (TEMPO, 0.5 g). A 10% aqueous sodium hypochlorite solution (1000 mL) was added in batches and the pH of the reaction mixture was adjusted to 7-8 using sodium bicarbonate while maintaining the reaction temperature between 5 and 20 °C. Upon completion of the reaction, the aqueous layer was separated, and the organic layer was washed with saturated aqueous sodium chloride (400 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give a white solid product in 95% yield.

References

[1] Patent: WO2010/78250, 2010, A1. Location in patent: Page/Page column 12
[2] Patent: WO2006/3677, 2006, A1. Location in patent: Page/Page column 10; 16
[3] Patent: US2011/280808, 2011, A1. Location in patent: Page/Page column 62
[4] Journal of medicinal chemistry, 1993, vol. 36, # 13, p. 1918 - 1919
[5] Patent: US2003/100596, 2003, A1

N-(4-Oxocyclohexyl)phthalimide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(4-Oxocyclohexyl)phthalimide manufacturers

Career Henan Chemical Co

Product: 4-(PHTHALIMIDO)-CYCLOHEXANONE 104618-32-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-22

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104618-32-8