Trityl candesartan
- Product Name
- Trityl candesartan
- CAS No.
- 139481-72-4
- Chemical Name
- Trityl candesartan
- Synonyms
- Triphenyl Candesartan;TRITYL CANDESARTAN;N-tityl candesartan;Trityl Candesaratan;N-Trityl Candesartan;N-trimethylcandesartan;Trityl Candesartan (C9);Tricycliccandesartan(C9);Candesartan Impurity 8;CANDESARTAN INTERMEDIATE A
- CBNumber
- CB0763835
- Molecular Formula
- C43H34N6O3
- Formula Weight
- 682.77
- MOL File
- 139481-72-4.mol
Trityl candesartan Property
- Melting point:
- 163-165°C
- Boiling point:
- 908.6±75.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 2.06±0.10(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I593
- Product name
- Tritylcandesartan
- Packaging
- 25mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- 075316
- Product name
- 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- APN0000444
- Product name
- TRITYL CANDESARTAN
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $327.6
- Updated
- 2021/12/16
- Product number
- 075316
- Product name
- 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $559
- Updated
- 2021/12/16
- Product number
- CM160539
- Product name
- 2-Ethoxy-1-((2''-(1-trityl-1H-tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylicacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $359
- Updated
- 2021/12/16
Trityl candesartan Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
2-Ethoxy-1-((2''-(1-trityl-1H-tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic Acid can be used as reagent/reactant in preparation of the anti-hypertensive drug candesartan cilexetil.
Uses
Candesartan analog as angiotensin II antagonist.
Synthesis
76-83-5
139481-59-7
139481-72-4
I. 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid (10 kg) was added to the reaction kettle along with dichloromethane (100 kg), and cooled down to 15°C. The temperature of the reaction system was increased to 15°C by adding triethylamine (4.5 kg). Triethylamine (4.5 kg) was slowly added dropwise, and after the dropwise addition was completed, the temperature of the reaction system was raised to 23 °C. Triphenylchloromethane (7kg) was added in batches and after completion of addition, the reaction was maintained at 23°C for 3.5 hours. The reaction progress was monitored by TLC (unfolding agent: dichloromethane/methanol=10:1, v/v, Rf=0.78). After completion of the reaction, the pH of the system was adjusted to 5.4 by adding 0.1 mol/L HCl (30 L), then 5 L of 9 mol/L HCl was added slowly to pH=2.2, and the reaction was allowed to stand for stratification to separate the aqueous and organic layers. The organic layer (about 60 L) was washed with saturated saline, transferred to a reduced pressure distillation unit, and dichloromethane was recovered under reduced pressure. Ethanol (65L) was added to the residue, warmed to 45°C and stirred for 3 hours until a large amount of white solid precipitated. The heating was stopped, cooled to room temperature, filtered, the filter cake was washed with a small amount of ethanol, and dried at 50°C under normal pressure for 12 hours to obtain 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid (white crystalline powder, 14.5 kg, yield 94.0%).
References
[1] Patent: CN105153124, 2018, B. Location in patent: Paragraph 0005; 0054; 0055; 0076; 0090
[2] Patent: WO2009/7986, 2009, A1. Location in patent: Page/Page column 13
[3] Patent: US2010/210852, 2010, A1. Location in patent: Page/Page column 5
[4] Patent: WO2009/7986, 2009, A1. Location in patent: Page/Page column 14
[5] Patent: WO2009/7986, 2009, A1. Location in patent: Page/Page column 14
Trityl candesartan Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trityl candesartan manufacturers
- Product
- Trityl Candesartan 139481-72-4
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-24
- Product
- Trityl candesartan 139481-72-4
- Price
- US $30.00-28.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.0% up
- Supply Ability
- 50 tons per month
- Release date
- 2022-09-28
- Product
- Trityl candesartan 139481-72-4
- Price
- US $8.20/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2021-12-23