2-HYDROXY-4-FLUOROPYRIDINE
- Product Name
- 2-HYDROXY-4-FLUOROPYRIDINE
- CAS No.
- 96530-75-5
- Chemical Name
- 2-HYDROXY-4-FLUOROPYRIDINE
- Synonyms
- uoropyridin-2-oL;4-fluoropyridin-2-o;4-Fluoropyridin-2-ol;4-FLUORO-2(1H)-PYRIDINONE;4-fluoro-1H-pyridin-2-one;4-Fluoropyridin-2(1H)-one;2-HYDROXY-4-FLUOROPYRIDINE;4-fluoro-2-hydroxypyridine;2(1H)-Pyridinone, 4-fluoro-;2-HYDROXY-4-FLUOROPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB0777467
- Molecular Formula
- C5H4FNO
- Formula Weight
- 113.09
- MOL File
- 96530-75-5.mol
2-HYDROXY-4-FLUOROPYRIDINE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- White to off-white
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F596313
- Product name
- 4-Fluoropyridin-2-ol
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- F596313
- Product name
- 4-Fluoropyridin-2-ol
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- F596313
- Product name
- 4-Fluoropyridin-2-ol
- Packaging
- 250mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 073535
- Product name
- 4-Fluoropyridin-2-ol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- PC201387
- Product name
- 4-Fluoropyridin-2(1H)-one
- Purity
- 98%
- Packaging
- 1g
- Price
- $218
- Updated
- 2021/12/16
2-HYDROXY-4-FLUOROPYRIDINE Chemical Properties,Usage,Production
Synthesis
38767-72-5
96530-75-5
General procedure for the synthesis of 4-fluoropyridin-2-one from 4-aminopyridin-2-one: 4-amino-2-pyridinone (1.85 g, 16.8 mmol) was slowly added to a cooled solution of HF-pyridine complex (70%, 13.1 mL) at 0 °C. The mixture was cooled to -20 °C. Potassium tert-butoxide (3.0 mL, 25.2 mmol) was slowly added. The reaction mixture was stirred at -20 °C for 0.5 h and then slowly warmed to room temperature. The reaction was kept for 2 hours and then finally heated at 60 °C for 1 hour. The mixture was cooled to 0 °C and left to stand. Sodium carbonate (Na2CO3) was added to neutralize. The aqueous layer was extracted with ethyl acetate (5 times), the organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Purification of the crude product by rapid chromatography on silica gel (dichloromethane/methanol: 95/5) afforded the target compound 4-fluoropyridin-2-one (1.14 g, 60% yield) as a colorless solid.
References
[1] Synlett, 2016, vol. 27, # 1, p. 67 - 69
2-HYDROXY-4-FLUOROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-HYDROXY-4-FLUOROPYRIDINE Suppliers
- Tel
- +49 5662 408730
- Fax
- +49 5662 4087320
- info@synchem.de
- Country
- Germany
- ProdList
- 4705
- Advantage
- 70
View Lastest Price from 2-HYDROXY-4-FLUOROPYRIDINE manufacturers
- Product
- 2-HYDROXY-4-FLUOROPYRIDINE 96530-75-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25