Tryptophol
- Product Name
- Tryptophol
- CAS No.
- 526-55-6
- Chemical Name
- Tryptophol
- Synonyms
- 2-(1H-INDOL-3-YL)ETHAN-1-OL;3-(2-HYDROXYETHYL)INDOLE;INDOLE-3-ETHANOL;IEA;Indoleethanol;3-INDOLEETHANOL;B-3-INDOLYLETHANOL;BETA-3-INDOLYLETHANOL;DK803;NSC 3884
- CBNumber
- CB0782869
- Molecular Formula
- C10H11NO
- Formula Weight
- 161.2
- MOL File
- 526-55-6.mol
Tryptophol Property
- Melting point:
- 56-59 °C(lit.)
- Boiling point:
- 174 °C (2.02527 mmHg)
- Density
- 1.0840 (rough estimate)
- refractive index
- 1.5200 (estimate)
- Flash point:
- 255 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- methanol: 0.1 g/mL, clear
- pka
- 15.16±0.10(Predicted)
- form
- Crystalline Mass, Crystals, Flakes or Powder
- color
- Off-white to brown
- Water Solubility
- 10 g/L (20 ºC)
- Merck
- 14,9798
- BRN
- 125553
- InChIKey
- MBBOMCVGYCRMEA-UHFFFAOYSA-N
- LogP
- 1.280 (est)
- CAS DataBase Reference
- 526-55-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-indole-3-ethanol(526-55-6)
- EPA Substance Registry System
- 1H-Indole-3-ethanol (526-55-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T90301
- Product name
- 3-(2-Hydroxyethyl)indole
- Purity
- 97%
- Packaging
- 5g
- Price
- $103
- Updated
- 2024/03/01
- Product number
- I0030
- Product name
- 3-Indoleethanol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $35
- Updated
- 2024/03/01
- Product number
- I0030
- Product name
- 3-Indoleethanol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $101
- Updated
- 2024/03/01
- Product number
- L02555
- Product name
- Tryptophol, 97%
- Packaging
- 1g
- Price
- $26.65
- Updated
- 2024/03/01
- Product number
- L02555
- Product name
- Tryptophol, 97%
- Packaging
- 5g
- Price
- $86
- Updated
- 2024/03/01
Tryptophol Chemical Properties,Usage,Production
Chemical Properties
3-(2-Hydroxyethyl)indole [526-55-6], tryptophol, C10H11NO, Mr 161.20, mp 59 ℃, bp 174 ℃, (2 kPa) forms colorless prisms or flakes that are readily soluble in methanol, ethanol, diethyl ether, chloroform, and acetone, soluble in benzene, and slightly soluble in water. It is produced by reacting methyl-1H-indole-3-acetate with lithium aluminum hydride, or through reduction of methyl-1H-indole-3-glyoxylate with sodium borohydride. The antihypertensive Indoramin is produced from tryptophol.
Uses
Tryptophol is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.
Uses
Reactant for preparation of:
- Inhibitors of the C-terminal domain of RNA polymerase II and their antitumor activities
- Anti-HIV-1 agents
- Inhibitors of Protein-Protein Interactions
- Partial agonists of the serotonin 5-HT1A receptor
- Growth hormone secretagogues
- Vascular endothelial growth factor (VEGF) inhibitors
- A2B adenosine receptor ligands
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- Inhibitors of interleukine 6
- Dual binding site acetylcholinesterase inhibitors
Definition
ChEBI: An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2.
Synthesis Reference(s)
Canadian Journal of Chemistry, 42, p. 485, 1964 DOI: 10.1139/v64-070
Purification Methods
Crystallise it from diethyl ether/pet ether, *C6H6, *C6H6/pet ether. The picrate has m 100-101o (from *C6H6). [Beilstein 21 I 218, 21 II 49, 21 III/IV 788, 21/3 V 61.]
Tryptophol Preparation Products And Raw materials
Raw materials
Preparation Products
Tryptophol Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
- Tel
- --
- Fax
- --
- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74
- Tel
- --
- Fax
- --
- labchem-tec@wako-chem.co.jp
- Country
- Japan
- ProdList
- 6819
- Advantage
- 80
View Lastest Price from Tryptophol manufacturers
- Product
- Tryptophol 526-55-6
- Price
- US $25.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99.5%
- Supply Ability
- 100 mt
- Release date
- 2024-11-20
- Product
- Tryptophol 526-55-6
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-09-21
- Product
- Tryptophol 526-55-6
- Price
- US $5.70/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-09