(+/-)-BLEBBISTATIN
- Product Name
- (+/-)-BLEBBISTATIN
- CAS No.
- 674289-55-5
- Chemical Name
- (+/-)-BLEBBISTATIN
- Synonyms
- (±)Bebbistatin;(+/-)-BLEBBISTATIN;(R)-(+)-BLEBBISTATIN;E1249 (+/-)-Blebbi- Calbiochem;(±)-Blebbistatin (DMSO Solution);Blebbistatin,Inhibitor,Myosin,inhibit;(±)-Blebbistatin, inhibitor of myosin II;3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one;3a-hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one;(+/-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE
- CBNumber
- CB0787697
- Molecular Formula
- C18H16N2O2
- Formula Weight
- 292.33
- MOL File
- 674289-55-5.mol
(+/-)-BLEBBISTATIN Property
- Melting point:
- 210-212°C
- Boiling point:
- 507.3±60.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Chloroform (Slightly), Dichloromethane, DMSO, Ethyl Acetate, Methanol
- form
- Bright yellow solid.
- pka
- 11.15±0.20(Predicted)
- color
- Yellow
- CAS DataBase Reference
- 674289-55-5
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 203390
- Product name
- (±)-Blebbistatin - CAS 674289-55-5 - Calbiochem
- Packaging
- 5mg
- Price
- $272
- Updated
- 2024/03/01
- Product number
- 13186
- Product name
- (±)-Blebbistatin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 13186
- Product name
- (±)-Blebbistatin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $189
- Updated
- 2024/03/01
- Product number
- 13186
- Product name
- (±)-Blebbistatin
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $336
- Updated
- 2024/03/01
- Product number
- 13186
- Product name
- (±)-Blebbistatin
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $629
- Updated
- 2024/03/01
(+/-)-BLEBBISTATIN Chemical Properties,Usage,Production
Description
(±)-Blebbistatin is a racemic mixture of (–)-blebbistatin and (+)-blebbistatin , the active and inactive forms, respectively. (–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 8 μM). Through these effects, (–)-blebbistatin blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin are more stable forms of (–)-blebbistatin and (+)-blebbistatin, respectively. The addition of a nitro group stabilizes the molecules to circumvent their degradation by prolonged blue light exposure. (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin have the same stereochemistry of the active and inactive enantiomers, respectively.
Chemical Properties
Bright Yellow Solid
Uses
(±)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, blebbistatin blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells. Blebbistatin is inactivated by UV light, which may be particularly important in fluorescent cell imaging applications. Purified enantiomers of Blebbistatin are also available from Cayman ((?)-Blebbistatin - ).
Uses
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. (±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
Definition
ChEBI: A pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase ac ivity of non-muscle myosin II.
Biological Activity
Selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
storage
Store at +4°C
(+/-)-BLEBBISTATIN Preparation Products And Raw materials
Raw materials
Preparation Products
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