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(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE

Product Name
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
CAS No.
354811-10-2
Chemical Name
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
Synonyms
IKK2-IN-4;IKK-2 INHIBITOR VI;IKK2 Inhibitor VI,IKK-2 Inhibitor VI;(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide;2-(carbamoylamino)-5-phenylthiophene-3-carboxamide;2-[(AMinocarbonyl)aMino]-5-phenyl-3-thiophenecarboxaMide;3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-phenyl-;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide|||IKK2 Inhibitor IV
CBNumber
CB0789277
Molecular Formula
C12H11N3O2S
Formula Weight
261.3
MOL File
Mol file
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(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Property

Melting point:
>210°C (dec.)
Boiling point:
445.6±45.0 °C(Predicted)
Density 
1.426±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO, Methanol (Slightly)
pka
14.00±0.70(Predicted)
form 
Solid
color 
Light Beige to Light Brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17276
Product name
IKK2 Inhibitor VI
Purity
≥95%
Packaging
500μg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
17276
Product name
IKK2 Inhibitor VI
Purity
≥95%
Packaging
1mg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
17276
Product name
IKK2 Inhibitor VI
Purity
≥95%
Packaging
5mg
Price
$480
Updated
2024/03/01
TRC
Product number
P338250
Product name
(5-Phenyl-2-ureido)thiophene-3-carboxamide
Packaging
2.5mg
Price
$145
Updated
2021/12/16
AK Scientific
Product number
8102CP
Product name
5-Phenyl-2-Ureidothiophene-3-Carboxamide
Packaging
5mg
Price
$633
Updated
2021/12/16
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(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Chemical Properties,Usage,Production

Description

Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.

Uses

(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE is an inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.

Uses

An ureido-thiophenecarboxamide compound that acts as a potent inhibitor of IKK-2 (InhibitorVI).

IC 50

IKK-2: 25 nM (IC50)

References

[1] ANDREW BAXTER  et al. et al. Hit-to-Lead Studies: The Discovery of Potent, Orally Active, Thiophenecarboxamide IKK-2 Inhibitors.[J]. ChemInform, 2004, 35 39. DOI: 10.1002/chin.200439220
[2] LUCY A MCNAMARA  Kathleen L C  Janani A Ganesh. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.[J]. Journal of Virology, 2012: 9337-9350. DOI: 10.1128/jvi.00895-12
[3] VASU PUNJ  Preet M C  Hittu Matta. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma.[J]. PLoS ONE, 2012: e37498. DOI: 10.1371/journal.pone.0037498

(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Suppliers

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J & K SCIENTIFIC LTD.
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354811-10-2, (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDERelated Search:


  • (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
  • IKK-2 INHIBITOR VI
  • 2-[(AMinocarbonyl)aMino]-5-phenyl-3-thiophenecarboxaMide
  • 2-(carbamoylamino)-5-phenylthiophene-3-carboxamide
  • 3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-phenyl-
  • 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide
  • IKK2 Inhibitor VI,IKK-2 Inhibitor VI
  • 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide|||IKK2 Inhibitor IV
  • IKK2-IN-4
  • 354811-10-2
  • Aromatics Compounds
  • Aromatics
  • Inhibitors
  • Sulfur & Selenium Compounds
  • An ureido-thiophenecarboxamide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of IKK-2 (IC50 = 13 nM).