ChemicalBook > CAS DataBase List > 2-AMINO-4-METHOXYCARBONYL BENZOIC ACID

2-AMINO-4-METHOXYCARBONYL BENZOIC ACID

Product Name
2-AMINO-4-METHOXYCARBONYL BENZOIC ACID
CAS No.
85743-02-8
Chemical Name
2-AMINO-4-METHOXYCARBONYL BENZOIC ACID
Synonyms
2-Carboxy-5-(methoxycarbonyl)aniline;2-AMINO-4-METHOXYCARBONYL BENZOIC ACID;2-amino-benzene-1,4-dicarboxylic acid,4-methyl ester;1,4-Benzenedicarboxylic acid, 2-amino-, 4-methyl ester
CBNumber
CB0801928
Molecular Formula
C9H9NO4
Formula Weight
195.17
MOL File
85743-02-8.mol
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2-AMINO-4-METHOXYCARBONYL BENZOIC ACID Property

Melting point:
213 °C
Boiling point:
397.7±32.0 °C(Predicted)
Density 
1.373±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
4.51±0.10(Predicted)
color 
Yellow
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M285850
Product name
Methyl3-Amino-4-carboxybenzoate
Packaging
1g
Price
$130
Updated
2021/12/16
TRC
Product number
M285850
Product name
Methyl3-Amino-4-carboxybenzoate
Packaging
10g
Price
$880
Updated
2021/12/16
AK Scientific
Product number
0855AF
Product name
2-Amino-4-(methoxycarbonyl)benzoicacid
Packaging
250mg
Price
$126
Updated
2021/12/16
Apolloscientific
Product number
OR40063
Product name
2-Amino-4-(methoxycarbonyl)benzoicacid
Packaging
1g
Price
$157
Updated
2021/12/16
SynQuest Laboratories
Product number
4657-1-48
Product name
2-Amino-4-(methoxycarbonyl)benzoic acid
Packaging
1g
Price
$173
Updated
2021/12/16
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2-AMINO-4-METHOXYCARBONYL BENZOIC ACID Chemical Properties,Usage,Production

Uses

Methyl 3-Amino-4-carboxybenzoate is an intermediate used to prepare (N-methylpiperazinyl)-contg. derivatives of quinazolinone as fungal efflux pump inhibitors.

Synthesis

55737-66-1

85743-02-8

General procedure for the synthesis of 2-amino-4-methoxycarbonylbenzoic acid from methyl 3-nitro-4-carboxybenzoate: preparation Example 12 Step 1. A suspension of 2-amino-4-(methoxycarbonyl)benzoic acid 12BA (4-methoxycarbonyl)-2-nitrobenzoic acid (12A) (10.0 g, 44.4 mmol) with 5% Pd/C (4.0 g) was reacted in a 1. 1 MeOH/H2O (50 mL) were mixed and placed under hydrogenation conditions (H2, 50 psi) for 16 hrs of reaction. Upon completion of the reaction, the mixture was filtered through a Celite pad, washed with MeOH, and the filtrate was concentrated to give the product 12B (6.51 g, yield = 75%). Mass spectral analysis showed MS (M+H) = 196.

References

[1] Patent: WO2012/51036, 2012, A1. Location in patent: Page/Page column 79
[2] Patent: US5541178, 1996, A
[3] Monatshefte fuer Chemie, 1907, vol. 28, p. 822

2-AMINO-4-METHOXYCARBONYL BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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85743-02-8, 2-AMINO-4-METHOXYCARBONYL BENZOIC ACIDRelated Search:

AURORA 6366 AURORA 6418 AURORA 11276 AURORA 5741 AURORA 6245 DIMETHYL 2-[(PHENOXYCARBONYL)AMINO]TEREPHTHALATE AURORA 7335 AURORA 5287 AURORA 5472 AURORA 5222 Dimethyl aminoterephthalate AURORA 22944 AKOS B007547 AURORA 5255 AURORA 6367 Dimethyl nitroterephthalate

  • 2-AMINO-4-METHOXYCARBONYL BENZOIC ACID
  • 2-Carboxy-5-(methoxycarbonyl)aniline
  • 2-amino-benzene-1,4-dicarboxylic acid,4-methyl ester
  • 1,4-Benzenedicarboxylic acid, 2-amino-, 4-methyl ester
  • 85743-02-8
  • Esters
  • Phenyls & Phenyl-Het