Tubulin inhibitor 6
- Product Name
- Tubulin inhibitor 6
- CAS No.
- 105925-39-1
- Chemical Name
- Tubulin inhibitor 6
- Synonyms
- iHAP1;Tubulin inhibitor 6;iHAP1 （Tubulin inhibitor 6）;Tubulin inhibitor 6, 10 mM in DMSO;2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine;2-chloro-10-(4-methoxybenzeneformyl)-10H-phenethiazine;(2-chlorophenothiazin-10-yl)-(4-methoxyphenyl)methanone;(2-Chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone;Methanone, (2-chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)-;DLD-1,cycle,K562,Tubulin inhibitor-6,tubulin,COLO-205,SKOV3,Tubulin inhibitor 6,451LU,Inhibitor,Microtubule/Tubulin,Tubulin inhibitor6,SW480,Antiproliferative,inhibit,NCIH460,BT549,cell
- CBNumber
- CB08054568
- Molecular Formula
- C20H14ClNO2S
- Formula Weight
- 367.85
- MOL File
- 105925-39-1.mol
Tubulin inhibitor 6 Property
- Melting point:
- 155-157 °C
- Boiling point:
- 549.1±50.0 °C(Predicted)
- Density
- 1.364±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 62.5 mg/mL (169.91 mM)
- form
- A crystalline solid
- pka
- -5.56±0.20(Predicted)
- color
- White to off-white
- InChIKey
- CSWHYHPUEDNIQY-UHFFFAOYSA-N
- SMILES
- S1c2c(cc(cc2)Cl)N(c4c1cccc4)C(=O)c3ccc(cc3)OC
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Axon3400
- Product name
- Tubulininhibitor6-iHAP1
- Purity
- 99%
- Packaging
- 10mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- CS-0119638
- Product name
- Tubulininhibitor6
- Purity
- 99.51%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0119638
- Product name
- Tubulininhibitor6
- Purity
- 99.51%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- Axon3400
- Product name
- Tubulininhibitor6-iHAP1
- Purity
- 99%
- Packaging
- 50mg
- Price
- $297
- Updated
- 2021/12/16
- Product number
- 020514
- Product name
- Tubulininhibitor6
- Packaging
- 001
- Price
- $500
- Updated
- 2021/12/16
Tubulin inhibitor 6 Chemical Properties,Usage,Production
Uses
Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].
Biological Activity
Tubulin inhibitor 6 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and efficiently kills malignant cells.
in vitro
Tubulin inhibitor 6 displays submicromolar antiproliferative activity.
target
| Target | Value |
| PP2A () |