ChemicalBook > CAS DataBase List > E3 ligase Ligand-Linker Conjugates 38
E3 ligase Ligand-Linker Conjugates 38
- Product Name
- E3 ligase Ligand-Linker Conjugates 38
- CAS No.
- 2095244-52-1
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 38
- Synonyms
- cIAP1 Ligand-Linker Conjugates 12;E3 ligase Ligand-Linker Conjugates 38;tert-butyl N-[(1S)-1-{[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(3-{2-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]ethoxy}benzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]carbamoyl}ethyl]-N-methylcarbamate;Benzenesulfonic acid, 4-methyl-, 2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl ester
- CBNumber
- CB08054715
- Molecular Formula
- C46H64N4O12S2
- Formula Weight
- 929.15
- MOL File
- 2095244-52-1.mol
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E3 ligase Ligand-Linker Conjugates 38 Property
- Boiling point:
- 999.9±65.0 °C(Predicted)
- Density
- 1.239±0.06 g/cm3(Predicted)
- pka
- 14.02±0.46(Predicted)
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E3 ligase Ligand-Linker Conjugates 38 Chemical Properties,Usage,Production
Uses
cIAP1 Ligand-Linker Conjugates 12 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 12 can be used to design SNIPERs[1].
IC 50
cIAP1
References
[1] Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570. DOI:10.1074/jbc.M116.768853
E3 ligase Ligand-Linker Conjugates 38 Preparation Products And Raw materials
Raw materials
Preparation Products
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E3 ligase Ligand-Linker Conjugates 38 Suppliers
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2095244-52-1, E3 ligase Ligand-Linker Conjugates 38Related Search:
E3 ligase Ligand 12
Acetic acid, 2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]-
E3 ligase Ligand-Linker Conjugates 37
E3 ligase Ligand-Linker Conjugates 41
E3 ligase Ligand-Linker Conjugates 33
E3 ligase Ligand 11
E3 ligase Ligand-Linker Conjugates 36
E3 ligase Ligand-Linker Conjugates 39
E3 ligase Ligand-Linker Conjugates 34
E3 ligase Ligand 14
Carbamic acid, N-[(1S)-2-[[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(3-hydroxybenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]methylamino]-1-methyl-2-oxoethyl]-N-methyl-, 1,1-dimethylethyl ester