ChemicalBook > CAS DataBase List > (Rac)-Benpyrine

(Rac)-Benpyrine

Product Name
(Rac)-Benpyrine
CAS No.
1333714-43-4
Chemical Name
(Rac)-Benpyrine
Synonyms
(Rac)-Benpyrine;Benpyrine racemate;(Rac)-Benpyrine, 10 mM in DMSO;4-((9H-Purin-6-yl)amino)-1-benzylpyrrolidin-2-one;2-Pyrrolidinone, 1-(phenylmethyl)-4-(9H-purin-6-ylamino)-;autoimmune,Inhibitor,anti-inflammatory,(Rac) Benpyrine,(Rac)-Benpyrine,Tumor Necrosis Factor Receptor,IFN-γ,IL-1β,(Rac)Benpyrine,inhibit,TNF Receptor,IL-6,NF-κB,TNFR,TNF-α,IL-10
CBNumber
CB08057640
Molecular Formula
C16H16N6O
Formula Weight
308.34
MOL File
1333714-43-4.mol
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(Rac)-Benpyrine Property

Boiling point:
699.1±55.0 °C(Predicted)
Density 
1.456±0.06 g/cm3(Predicted)
solubility 
DMF: 1 mg/ml
form 
A solid
pka
10.01±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC40738
Product name
(Rac)-Benpyrine
Purity
>98%
Packaging
100mg
Price
$550
Updated
2021/12/16
DC Chemicals
Product number
DC40738
Product name
(Rac)-Benpyrine
Purity
>98%
Packaging
250mg
Price
$900
Updated
2021/12/16
DC Chemicals
Product number
DC40738
Product name
(Rac)-Benpyrine
Purity
>98%
Packaging
1g
Price
$1800
Updated
2021/12/16
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(Rac)-Benpyrine Chemical Properties,Usage,Production

Uses

(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].

in vivo

(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1].

Animal Model:Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1]
Dosage:25 mg/kg, 50 mg/kg
Administration:Oral gavage; daily; for 3 weeks
Result:The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.

References

[1] Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A.

(Rac)-Benpyrine Preparation Products And Raw materials

Raw materials

Preparation Products

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(Rac)-Benpyrine Suppliers

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1333714-43-4, (Rac)-BenpyrineRelated Search:


  • (Rac)-Benpyrine
  • 4-((9H-Purin-6-yl)amino)-1-benzylpyrrolidin-2-one
  • autoimmune,Inhibitor,anti-inflammatory,(Rac) Benpyrine,(Rac)-Benpyrine,Tumor Necrosis Factor Receptor,IFN-γ,IL-1β,(Rac)Benpyrine,inhibit,TNF Receptor,IL-6,NF-κB,TNFR,TNF-α,IL-10
  • 2-Pyrrolidinone, 1-(phenylmethyl)-4-(9H-purin-6-ylamino)-
  • Benpyrine racemate
  • (Rac)-Benpyrine, 10 mM in DMSO
  • 1333714-43-4