Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate
- Product Name
- Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate
- CAS No.
- 2089251-33-0
- Chemical Name
- Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate
- Synonyms
- Lipid 5;Lipid 5 (SM-86);nonyl 8-[2-hydroxyethyl-[8-(1-octylnonoxy)-8-oxo-octyl]amino]octanoate;1-Octylnonyl 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]octanoate;Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate;Octanoic acid, 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-, 1-octylnonyl ester
- CBNumber
- CB08066419
- Molecular Formula
- C44H87NO5
- Formula Weight
- 710.17
- MOL File
- 2089251-33-0.mol
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Property
- Boiling point:
- 725.8±50.0 °C(Predicted)
- Density
- 0.925±0.06 g/cm3(Predicted)
- solubility
- Soluble in Ethanol, DMSO, DMF
- form
- Liquid
- pka
- 14.67±0.10(Predicted)
- color
- Colorless to light yellow
- InChIKey
- ABCVHPIKBGRCJA-UHFFFAOYSA-N
- SMILES
- C(OC(CCCCCCCC)CCCCCCCC)(=O)CCCCCCCN(CCO)CCCCCCCC(OCCCCCCCCC)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 013331
- Product name
- Lipid5
- Packaging
- 002
- Price
- $750
- Updated
- 2021/12/16
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Chemical Properties,Usage,Production
Description
7-[(2-Hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]heptyl 2-octyldecanoate, analog of ALC-0315, is a ionizable, physiological pH cationic synthetic lipid that is used with other lipids to form lipid nanoparticles(LNP) for drug delivery.
Uses
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects[1].
in vivo
Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart[1].
References
[1] Staci Sabnis, et al. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519. DOI:10.1016/j.ymthe.2018.03.010
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate manufacturers
- Product
- Lipid 5
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle , 10g/bottle, 100g/bottle
- Release date
- 2024-11-26