1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]-

Product Name: 1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]-
CAS No.: 2449301-27-1
Chemical Name: 1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]-
Synonyms: CID 137319705;GSK-2643943A,GSK2643943A;GSK2643943A, 10 mM in DMSO;2-amino-6-(3-fluorostyryl)-1H-indole-3-carbonitrile;1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]-
CBNumber: CB08118811
Molecular Formula: C17H12FN3
Formula Weight: 277.3
MOL File: 2449301-27-1.mol

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1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]- Property

Boiling point:: 540.4±50.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
solubility: DMSO:90.0(Max Conc. mg/mL);324.56(Max Conc. mM)
Ethanol:8.0(Max Conc. mg/mL);28.85(Max Conc. mM)
pka: 16.49±0.30(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0041056
Product name: GSK2643943A
Purity: 98.31%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0041056
Product name: GSK2643943A
Purity: 98.31%
Packaging: 10mg
Price: $165
Updated: 2021/12/16

ChemScene

Product number: CS-0041056
Product name: GSK2643943A
Purity: 98.31%
Packaging: 25mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0041056
Product name: GSK2643943A
Purity: 98.31%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0041056
Product name: GSK2643943A
Purity: 98.31%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

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1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]- Chemical Properties,Usage,Production

Uses

GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) [1][2].

in vivo

GSK2643943A (5 mg/kg, i.p., daily, for 6 days) potentiates oHSV-1-induced oncolysis in SCC9 tumors^[2].
? GSK2643943A (2.5 mg/kg, i.p., daily, for 9 days) plays a regulatory role in oHSV-1 T1012G replication and oncolysis in SCC7 cells^[2].

Animal Model:	The subcutaneous xenograft model^[2]. (SCC9 or SCC7 cells (8×10⁶ cells or 1×10⁶ cells), 5-week-old, female, BALB/c nude mice or C3H/HeN mice, four groups, n = 6-7, per group)^[2]
Dosage:	5 mg/kg
Administration:	GSK2643943A (alone): intraperitoneal administration, daily, for 6 days. GSK2643943A (combination): intraperitoneal administration, daily for 6 days + intratumoral injection with 50 mL of 1×10⁶ PFU T1012G in PBS on day 1, day 4, and day 7.
Result:	Caused a visible drop of tumor volumes and significantly reduced the tumor volumes in mice with combined treatment of GSK2643943A and oHSV-1 T1012G. Increased slightly viral ICP0 and gD mRNA accumulation in SCC9 tumors.

Animal Model:	The SCC7 mouse model^[2].
Dosage:	2.5 mg/kg
Administration:	GSK2643943A (alone): intraperitoneal administration, daily, for 9 days. GSK2643943A (combination): intraperitoneal administration, daily, for 9 days + intratumoral injection, with 50 mL of 1×10⁷ PFU T1012G in PBS on days 1, 4, 7, and 10.
Result:	Caused a visible drop of tumor volumes, significantly reduced in mice with combined treatment of GSK and oHSV-1 T1012G. Increased slightly viral ICP0 and gD mRNA accumulation in SCC7 tumors.

References

[1] Nishi Kumari, et al. Targeting the Ubiquitin Proteasome System in Cancer. Shahzad, Hafiz Naveed (2018). Neoplasm Targeting the Ubiquitin Proteasome System in Cancer. , 10.5772/intechopen.69560(Chapter 8).
[2] Ruitao Lu, et al. USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells. Mol Ther Oncolytics. 2021 Nov 11;23:477-487. DOI:10.1016/j.omto.2021.11.004

1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]- Suppliers

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2449301-27-1, 1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]-Related Search:

1H-Indole-3-carbonitrile, 2-amino-6-[2-(3-fluorophenyl)ethenyl]-

GSK-2643943A,GSK2643943A

2-amino-6-(3-fluorostyryl)-1H-indole-3-carbonitrile

CID 137319705

GSK2643943A, 10 mM in DMSO

2449301-27-1