1,5,9-Triazacyclododecane, 3-methylene-1,5-bis[(4-methylphenyl)sulfonyl]-9-(phenylmethyl)-
- Product Name
- 1,5,9-Triazacyclododecane, 3-methylene-1,5-bis[(4-methylphenyl)sulfonyl]-9-(phenylmethyl)-
- CAS No.
- 182316-44-5
- Chemical Name
- 1,5,9-Triazacyclododecane, 3-methylene-1,5-bis[(4-methylphenyl)sulfonyl]-9-(phenylmethyl)-
- Synonyms
- Cyclotriazadisulfonamide;1,5,9-Triazacyclododecane, 3-methylene-1,5-bis[(4-methylphenyl)sulfonyl]-9-(phenylmethyl)-
- CBNumber
- CB08144342
- Molecular Formula
- C31H39N3O4S2
- Formula Weight
- 581.79
- MOL File
- 182316-44-5.mol
1,5,9-Triazacyclododecane, 3-methylene-1,5-bis[(4-methylphenyl)sulfonyl]-9-(phenylmethyl)- Property
- Melting point:
- 160-164 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 706.2±70.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 7.98±0.20(Predicted)
- form
- Solid
- color
- White to off-white
1,5,9-Triazacyclododecane, 3-methylene-1,5-bis[(4-methylphenyl)sulfonyl]-9-(phenylmethyl)- Chemical Properties,Usage,Production
Uses
Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor[1][2][3].
IC 50
HIV-1
References
[1] Kurt Vermeire, et al. CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor. Curr HIV Res. 2008 May;6(3):246-56. DOI:10.2174/157016208784324958
[2] Victor Van Puyenbroeck, et al. Preprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide. Traffic. 2020 Feb;21(2):250-264. DOI:10.1111/tra.12713
[3] Pauwels E, et al. Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway. Int J Mol Sci. 2021 Nov 5;22(21):12007. DOI:10.3390/ijms222112007
1,5,9-Triazacyclododecane, 3-methylene-1,5-bis[(4-methylphenyl)sulfonyl]-9-(phenylmethyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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