Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4)

Product Name: Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4)
CAS No.: 1854126-47-8
Chemical Name: Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4)
Synonyms: HydroxychloroquineSulfateEPImpurityC-d4;2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]amino]-ethan-1,1,2,2-d4-ol;Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4)
CBNumber: CB08176204
Molecular Formula: C16H22ClN3O
Formula Weight: 307.82
MOL File: 1854126-47-8.mol

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Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) Property

storage temp.: Store at -20°C
solubility: DMF: Soluble,DMSO: Soluble,Methanol: Soluble
form: A solid

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Hazard and Precautionary Statements (GHS)

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Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) Chemical Properties,Usage,Production

Uses

Cletoquine-d4 is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

Biological Activity

Desethyl hydroxychloroquine-d4 is intended for use as an internal standard for the quantification of desethyl hydroxychloroquine by GC- or LC-MS. Desethyl hydroxychloroquine is an active metabolite of hydroxychloroquine .1 It is formed via the desethylation of hydroxychloroquine in the liver, a process mediated by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP3A5, and CYP2C8.

IC 50

Plasmodium

References

1.Charlier, B., Pingeon, M., Dal Piaz, F., et al.Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole bloodBiomed. Chromatogr.32(8)e4258(2018)

Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) Suppliers

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1854126-47-8, Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4)Related Search:

Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4)

HydroxychloroquineSulfateEPImpurityC-d4

2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]amino]-ethan-1,1,2,2-d4-ol

1854126-47-8