2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)-

Product Name: 2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)-
CAS No.: 2207541-30-6
Chemical Name: 2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)-
Synonyms: Lenalidomide-I;3-(4-iodo-1-oxoisoindolin-2-yl)piperidine-2,6-dione;2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)-
CBNumber: CB08182416
Molecular Formula: C13H11IN2O3
Formula Weight: 370.14
MOL File: 2207541-30-6.mol

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2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- Property

Boiling point:: 601.2±55.0 °C(Predicted)
Density: 1.876±0.06 g/cm3(Predicted)
solubility: DMSO : 25 mg/mL (67.54 mM; Need ultrasonic)
pka: 10.67±0.40(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- Chemical Properties,Usage,Production

Biological Activity

Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 [1]. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

References

[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.

2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2207541-30-6, 2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)-Related Search:

2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)-

3-(4-iodo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Lenalidomide-I

2207541-30-6