4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE
- Product Name
- 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE
- CAS No.
- 652968-37-1
- Chemical Name
- 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE
- Synonyms
- MITOPBN;4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE
- CBNumber
- CB0821515
- Molecular Formula
- C33H37BrNO2P
- Formula Weight
- 590.54
- MOL File
- Mol file
4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.33 mg/ml
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 18809
- Product name
- MitoPBN
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $421
- Updated
- 2024/03/01
- Product number
- 8604DU
- Product name
- N-Tert-Butyl{4-[4-(triphenylphosphaniumyl)butoxy]phenyl}methanimineN-oxidebromide
- Packaging
- 10mg
- Price
- $565
- Updated
- 2021/12/16
4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Chemical Properties,Usage,Production
Description
MitoPBN is a mitochondria-targeted antioxidant.1 It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.
References
1. Murphy, M.P., Echtay, K.S., Blaikie, F.H., et al. Superoxide activates uncoupling proteins by generating carbon-
4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Preparation Products And Raw materials
Raw materials
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