ChemicalBook > CAS DataBase List > 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE

4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE

Product Name
4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE
CAS No.
652968-37-1
Chemical Name
4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE
Synonyms
MITOPBN;4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE
CBNumber
CB0821515
Molecular Formula
C33H37BrNO2P
Formula Weight
590.54
MOL File
Mol file
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4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Property

storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.33 mg/ml
form 
A solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18809
Product name
MitoPBN
Purity
≥95%
Packaging
10mg
Price
$421
Updated
2024/03/01
AK Scientific
Product number
8604DU
Product name
N-Tert-Butyl{4-[4-(triphenylphosphaniumyl)butoxy]phenyl}methanimineN-oxidebromide
Packaging
10mg
Price
$565
Updated
2021/12/16
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4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Chemical Properties,Usage,Production

Description

MitoPBN is a mitochondria-targeted antioxidant.1 It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.

References

1. Murphy, M.P., Echtay, K.S., Blaikie, F.H., et al. Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: Studies using a mitochondria-targeted spin trap derived from α-phenyl-N-tert-butylnitrone J. Biol. Chem. 278(49),48534-48545(2003).

4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Suppliers

China 5 United States 3 Global 8
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52925
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66

652968-37-1, 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDERelated Search:


  • 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE
  • MITOPBN
  • 652968-37-1