ChemicalBook > CAS DataBase List > N2-METHYL-PYRIDINE-2,3-DIAMINE

N2-METHYL-PYRIDINE-2,3-DIAMINE

Product Name: N2-METHYL-PYRIDINE-2,3-DIAMINE
CAS No.: 5028-20-6
Chemical Name: N2-METHYL-PYRIDINE-2,3-DIAMINE
Synonyms: IFLAB-BB F2113-0168;2-N-METHYLPYRIDINE-2,3-DIAMINE;N2-METHYL-PYRIDINE-2,3-DIAMINE;2,3-Pyridinediamine, N2-methyl-;N~2~-Methyl-2,3-pyridinediaMine (SALTDATA: FREE)
CBNumber: CB0825265
Molecular Formula: C6H9N3
Formula Weight: 123.16
MOL File: 5028-20-6.mol

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N2-METHYL-PYRIDINE-2,3-DIAMINE Property

Melting point:: 100-101 °C
Boiling point:: 145 °C
Density: 1.179±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 7.04±0.10(Predicted)
Appearance: Brown to purple Solid

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B496308
Product name: N2-Methylpyridine-2,3-diamine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B496308
Product name: N2-Methylpyridine-2,3-diamine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 052701
Product name: N2-Methyl-2,3-pyridinediamine
Packaging: 2.500g
Price: $720
Updated: 2021/12/16

Matrix Scientific

Product number: 052701
Product name: N2-Methyl-2,3-pyridinediamine
Packaging: 1g
Price: $500
Updated: 2021/12/16

Matrix Scientific

Product number: 052701
Product name: N2-Methyl-2,3-pyridinediamine
Packaging: 500mg
Price: $300
Updated: 2021/12/16

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N2-METHYL-PYRIDINE-2,3-DIAMINE Chemical Properties,Usage,Production

Uses

N2-Methylpyridine-2,3-diamine is a useful reagent in synthesis of imidazopyridines, which show tuberculostatic activity.

Synthesis

4093-88-3

5028-20-6

General procedure for the synthesis of N2-methyl-2,3-pyridinediamine from N-methyl-3-nitropyridin-2-amine: N-methyl-3-nitropyridin-2-amine (58.14 g, 0.38 mol) was dissolved in 1,2-dimethoxyethane (400 mL) under vigorous stirring. Activated carbon (2.9 g) was added to the resulting solution, refluxed for 2 hours and left at room temperature overnight. After displacing the reaction system with dry nitrogen, 10% Pd/C catalyst (1.75 g) was added. The mixture was heated to 40 °C and hydrazine monohydrate (54 mL, 1.08 mol) was slowly added dropwise over a period of 2 hours. After dropwise addition, the reaction mixture was refluxed for 2 h. After cooling, the reaction mixture was filtered through a column of diatomaceous earth (upper layer, 3 cm) and silica gel (lower layer, 5 cm, 13 cm diameter) to remove the catalyst. The filtrate layer was washed with 1,2-dimethoxyethane (300 mL). The filtrate was concentrated under reduced pressure to afford N2-methyl-2,3-pyridinediamine in 98% yield (46.2 g) as a brown crystalline solid. The product could be used directly in the subsequent reaction without further purification.

References

[1] Chemistry - A European Journal, 2017, vol. 23, # 57, p. 14173 - 14176
[2] Open Medicinal Chemistry Journal, 2018, vol. 12, # 1, p. 74 - 83
[3] Patent: WO2008/12622, 2008, A2. Location in patent: Page/Page column 57
[4] Patent: CN106831776, 2017, A. Location in patent: Paragraph 0100; 0101; 0102
[5] Patent: WO2012/121936, 2012, A2. Location in patent: Page/Page column 93-94

N2-METHYL-PYRIDINE-2,3-DIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N2-METHYL-PYRIDINE-2,3-DIAMINE manufacturers

Career Henan Chemical Co

Product: N2-METHYL-PYRIDINE-2,3-DIAMINE 5028-20-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95.0-99.8%
Supply Ability: 1KG;5KG 10KG; 100KG
Release date: 2019-09-02

5028-20-6, N2-METHYL-PYRIDINE-2,3-DIAMINERelated Search:

N3-Methylpyridine-2,3-diamine 2-METHYLAMINO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE Pirenzepine 3-AMINO-2-(METHYLAMINO)-5-(TRIFLUOROMETHYL)PYRIDINE DNPYR-DL-NORLEUCINE 1-(3-NITROPYRIDIN-2-YL)PIPERIDINE-4-CARBONITRILE 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE DNPYR-L-ISOLEUCINE MONOCYCLOHEXYL AMMONI UM 1-(3-NITROPYRIDIN-2-YL)PIPERIDINE-4-CARBOXAMIDE DNPY-DL-ALANINE N-(4-CHLOROBENZYL)-3-NITRO-2-PYRIDINAMINE N-[3-(1H-imidazol-1-yl)propyl]-3-nitropyridin-2-amine 3-nitro-N-(pyridin-3-ylmethyl)pyridin-2-amine 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4-(3-NITRO-2-PYRIDINYL)PIPERAZINE 3-nitro-N-[2-(pyridin-2-yl)ethyl]pyridin-2-amine DNPY-GLYCINE N1-(1-BROMO-4-NITRO-3-ISOQUINOLYL)BENZAMIDE DINITROPYRIDYL-DL-METHIONINE

IFLAB-BB F2113-0168

N~2~-Methyl-2,3-pyridinediaMine (SALTDATA: FREE)

N2-METHYL-PYRIDINE-2,3-DIAMINE

2-N-METHYLPYRIDINE-2,3-DIAMINE

2,3-Pyridinediamine, N2-methyl-

5028-20-6