BPAM344 >=98% (HPLC)

Product Name: BPAM344 >=98% (HPLC)
CAS No.: 1204572-55-3
Chemical Name: BPAM344 >=98% (HPLC)
Synonyms: BPAM-344;BPAM344 >=98% (HPLC);BPAM344, 10 mM in DMSO;2H-1,2,4-Benzothiadiazine, 4-cyclopropyl-7-fluoro-3,4-dihydro-, 1,1-dioxide;Ionotropic glutamate receptors,GluK3a,PAM,iGluR,BPAM344,BPAM 344,Inhibitor,BPAM-344,KAR,GluK1b,GluK2a,inhibit
CBNumber: CB08323468
Molecular Formula: C10H11FN2O2S
Formula Weight: 242.27
MOL File: 1204572-55-3.mol

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BPAM344 >=98% (HPLC) Property

Boiling point:: 415.9±55.0 °C(Predicted)
Density: 1.504±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (1031.91 mM; Need ultrasonic)
pka: 8.88±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2047
Product name: BPAM344
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $121
Updated: 2025/07/31

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BPAM344 >=98% (HPLC) Chemical Properties,Usage,Production

Uses

BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1].

Biological Activity

BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1]. BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics[1]. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1].

References

[1]. Anja Probst Larsen, et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol Pharmacol. 2017 Jun;91(6):576-585.

BPAM344 >=98% (HPLC) Preparation Products And Raw materials

Raw materials

Preparation Products

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1204572-55-3, BPAM344 >=98% (HPLC)Related Search:

BPAM344 >=98% (HPLC)

BPAM-344

Ionotropic glutamate receptors,GluK3a,PAM,iGluR,BPAM344,BPAM 344,Inhibitor,BPAM-344,KAR,GluK1b,GluK2a,inhibit

2H-1,2,4-Benzothiadiazine, 4-cyclopropyl-7-fluoro-3,4-dihydro-, 1,1-dioxide

BPAM344, 10 mM in DMSO

1204572-55-3