3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE

Product Name: 3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE
CAS No.: 37804-11-8
Chemical Name: 3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE
Synonyms: ACDPP HYDROCHLORIDE;3-amino-6-chloro-5-(dimethylamino)-N-2-pyridinyl-2-Pyrazinecarboxamide;2-Pyrazinecarboxamide, 3-amino-6-chloro-5-(dimethylamino)-N-2-pyridinyl-;3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE;3-amino-6-chloro-5-(dimethylamino)-N-(pyridin-2-yl)pyrazine-2-carboxamide hydrochloride
CBNumber: CB0838193
Molecular Formula: C12H13ClN6O
Formula Weight: 292.72
MOL File: 37804-11-8.mol

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3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE Property

storage temp.: Desiccate at RT
solubility: Soluble to 100 mM in DMSO
form: Powder
color: Light yellow to yellow
CAS DataBase Reference: 37804-11-8

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A192208
Product name: ACDPP
Packaging: 25mg
Price: $230
Updated: 2021/12/16

Usbiological

Product number: 254527
Product name: ACDPP hydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

ApexBio Technology

Product number: B6991
Product name: ACDPPhydrochloride
Packaging: 10mg
Price: $242
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001058
Product name: ACDPP HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $502.55
Updated: 2021/12/16

ApexBio Technology

Product number: B6991
Product name: ACDPPhydrochloride
Packaging: 50mg
Price: $1017
Updated: 2021/12/16

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3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

ACDPP is a specific mGluR5 antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist)[1].

Biological Activity

Antagonist at the mGlu 5 receptor (K i = 295 nM). Inhibits human mGlu 5 receptor-mediated calcium flux with an IC 50 of 134 nM.

References

[1] Wang H, et al. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008 Apr 23;28(17):4385-97. DOI:10.1523/JNEUROSCI.0646-08.2008

3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE Suppliers

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37804-11-8, 3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDERelated Search:

Pyrazinecarboxaldehyde, 5-(dimethylamino)- (9CI) 6-CHLORO-3,5-DIAMINO-2-PYRAZINECARBOXAMIDE 3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE

3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE

ACDPP HYDROCHLORIDE

3-amino-6-chloro-5-(dimethylamino)-N-2-pyridinyl-2-Pyrazinecarboxamide

2-Pyrazinecarboxamide, 3-amino-6-chloro-5-(dimethylamino)-N-2-pyridinyl-

3-amino-6-chloro-5-(dimethylamino)-N-(pyridin-2-yl)pyrazine-2-carboxamide hydrochloride

37804-11-8

C12H13ClN6OHCl