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MT1 BET inhibitor

Product Name
MT1 BET inhibitor
CAS No.
2060573-82-0
Chemical Name
MT1 BET inhibitor
Synonyms
MT1 BET inhibitor;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N,N'-3,6,9,12,15,18,21-heptaoxatricosane-1,23-diylbis[4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S,6'S)-
CBNumber
CB08382106
Molecular Formula
C54H66Cl2N10O9S2
Formula Weight
1134.2
MOL File
2060573-82-0.mol
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MT1 BET inhibitor Property

Density 
1.39±0.1 g/cm3(Predicted)
form 
Solid
pka
14.57±0.46(Predicted)
color 
Off-white to light yellow
InChIKey
JNSLBXJNVHYNNW-CXNSMIOJSA-N
SMILES
C(NC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2C(C)=C(C)SC=2N2C(C)=NN=C21)COCCOCCOCCOCCOCCOCCOCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2C(C)=C(C)SC=2N2C(C)=NN=C21
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0094777
Product name
MT1
Packaging
1mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0094777
Product name
MT1
Packaging
5mg
Price
$650
Updated
2021/12/16
ChemScene
Product number
CS-0094777
Product name
MT1
Packaging
10mg
Price
$1050
Updated
2021/12/16
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MT1 BET inhibitor Chemical Properties,Usage,Production

Uses

MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].

in vivo

MT1 (44.2 and 22.1 μmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1].
MT1 exhibits terminal t1/2 of 2.70 h in mice[1].

Animal Model:Leukemia xenograft models[1].
Dosage:44.2 and 22.1 μmol/kg.
Administration:Intraperitoneally for 14 subsequent days.
Result:Significantly reduced leukemic burden over the course of the study compared to either vehicle or JQ1.

References

[1] Minoru Tanaka, et al. Design and characterization of bivalent BET inhibitors. Nat Chem Biol. 2016 Dec;12(12):1089-1096. DOI:10.1038/nchembio.2209

MT1 BET inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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MT1 BET inhibitor Suppliers

China 6 United States 1 Global 7
Beijing Biocreative Technology Co., Ltd.
Tel
15522676233
Email
3007606172@qq.com
Country
China
ProdList
1248
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Shanghai Yimeixin Technology Co., LTD
Tel
Country
China
ProdList
210
Advantage
58
Kebeilai Pharmaceutical Biotech Co., Ltd.
Tel
+86-18240866958
Email
wangjasmine7289@gmail.com
Country
China
ProdList
1022
Advantage
58
Hebei Jiafan Trading Company Limited
Tel
+86-15354498258; +8615354498258
Email
sales01@jiafan88.com
Country
China
ProdList
208
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
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View Lastest Price from MT1 BET inhibitor manufacturers

Shanghai Yimeixin Technology Co., LTD
Product
MT-1 2060573-82-0
Price
US $0.00/box
Min. Order
1box
Purity
0.99
Supply Ability
10tons
Release date
2025-09-26
Hebei Jiafan Trading Company Limited
Product
MT1 BET inhibitor 2060573-82-0
Price
US $5.00/BOX
Min. Order
1BOX
Purity
99.99%
Supply Ability
100000000
Release date
2025-05-14
Hebei Jiafan Trading Company Limited
Product
MT1 BET inhibitor 2060573-82-0
Price
US $5.00/BOX
Min. Order
1BOX
Purity
99.99%
Supply Ability
100000000
Release date
2025-04-28

2060573-82-0, MT1 BET inhibitorRelated Search:


  • 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N,N'-3,6,9,12,15,18,21-heptaoxatricosane-1,23-diylbis[4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S,6'S)-
  • MT1 BET inhibitor
  • 2060573-82-0
  • C54H66Cl2N10O9S2