3-bromo-1H-pyrrolo[3,2-c]pyridine
- Product Name
- 3-bromo-1H-pyrrolo[3,2-c]pyridine
- CAS No.
- 23612-36-4
- Chemical Name
- 3-bromo-1H-pyrrolo[3,2-c]pyridine
- Synonyms
- 3-BROMO-5-AZAINDOLE;3-bromo-1H-pyrrolo[3,2-c]pyridine;1H-Pyrrolo[3,2-c]pyridine, 3-bromo-
- CBNumber
- CB0839802
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 23612-36-4.mol
3-bromo-1H-pyrrolo[3,2-c]pyridine Property
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- color
- Yellow
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 3H32-9-U6
- Product name
- 3-Bromo-5-azaindole
- Packaging
- 250mg
- Price
- $47
- Updated
- 2021/12/16
- Product number
- FB148536
- Product name
- 3-Bromo-5-azaindole
- Packaging
- 25mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- B10818
- Product name
- 3-Bromo-5-azaindole
- Purity
- 98%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB148536
- Product name
- 3-Bromo-5-azaindole
- Packaging
- 50mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 3H32-9-U6
- Product name
- 3-Bromo-5-azaindole
- Packaging
- 1g
- Price
- $141
- Updated
- 2021/12/16
3-bromo-1H-pyrrolo[3,2-c]pyridine Chemical Properties,Usage,Production
Synthesis
271-34-1
23612-36-4
Example 1 Synthesis of 3-bromo-5-azaindole Referring to Scheme 1 shown in Figure 1, 5-azaindole (3.0128 g, 25.51 mmol, source: Atlantic SciTech Group) was dissolved in 50 mL of acetonitrile in a 250 mL three-necked round-bottomed flask. The device was equipped with a magnetic stirrer, thermocouple, nitrogen inlet and outlet, and an ice bath cooling system. Solid CuBr2 (17.0 g, 76.53 mmol, 3 eq.) was added in batches over 10 min at 17 °C. The resulting green suspension was stirred at room temperature until the starting material was undetectable by thin layer chromatography (TLC) (ca. 1-2 h; unfolding agent was EtOAc/MeOH = 9:1, 5-azaindole Rf = 0.23, 3-bromo-5-azaindole Rf = 0.49). The reaction mixture was cooled to 10 °C and the reaction was quenched by the slow addition of a methanol solution of 1N ammonia (110 mL). The resulting blue solution was concentrated by rotary evaporation at room temperature and the residue was extracted with ethyl acetate (3 x 80 mL). The organic extract was dried over anhydrous Na2SO4, filtered and concentrated to about 50 mL. The residue was refluxed over heat until all solids were dissolved, followed by addition of hexane to the hot mixture until crystallization occurred. The resulting suspension was cooled in an ice bath, the product was collected by filtration, washed sequentially with cold EtOAc/hexane (1:3) and hexane, and dried to give 3-bromo-5-azaindole as an off-white solid in 3.52 g yield (70% yield).
References
[1] Synlett, 2007, # 2, p. 211 - 214
[2] Patent: WO2010/33981, 2010, A2. Location in patent: Page/Page column 27-28
[3] Patent: WO2011/113798, 2011, A2. Location in patent: Page/Page column 35
[4] Patent: US2013/102587, 2013, A1. Location in patent: Paragraph 0181; 0182
[5] Journal of Medicinal Chemistry, 1997, vol. 40, # 15, p. 2430 - 2433
3-bromo-1H-pyrrolo[3,2-c]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-bromo-1H-pyrrolo[3,2-c]pyridine manufacturers
- Product
- 3-BROMO-5-AZAINDOLE 23612-36-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-19